Transmission of toxoplasma gondii infection by liver transplantation

James T. Mayes, Barry J. O’ Connor, Robin Avery, William Castellani, William Carey

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Abstract

Toxoplasmosis is an important disease in immunocompromised hosts, particularly in patients with AIDS and in heart transplant recipients. Infection with Toxoplasma is less commonly seen in recipients of other solid organ transplants. We report a case of fulminant disseminated infection with Toxoplasma after liver transplantation. Despite numerous diagnostic studies including open lung biopsy, toxoplasmosis was diagnosed only at the time of autopsy and involved the brain, spinal cord, pituitary gland, lungs, and heart. Toxoplasmosis should be considered in the differential diagnosis of multiorgan failure in the early period after liver transplantation. If mismatched serologies could be identified then clinical suspicion might be higher and prophylactic or empirical therapy could be instituted. The United Network for Organ Sharing (Richmond, VA) should consider including serology for Toxoplasma in the testing of donors.

Original languageEnglish (US)
Pages (from-to)511-515
Number of pages5
JournalClinical Infectious Diseases
Volume21
Issue number3
DOIs
Publication statusPublished - Sep 1995

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All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Mayes, J. T., O’ Connor, B. J., Avery, R., Castellani, W., & Carey, W. (1995). Transmission of toxoplasma gondii infection by liver transplantation. Clinical Infectious Diseases, 21(3), 511-515. https://doi.org/10.1093/clinids/21.3.511