Transmission of toxoplasma gondii infection by liver transplantation

James T. Mayes, Barry J. O’ Connor, Robin Avery, William Castellani, William Carey

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Toxoplasmosis is an important disease in immunocompromised hosts, particularly in patients with AIDS and in heart transplant recipients. Infection with Toxoplasma is less commonly seen in recipients of other solid organ transplants. We report a case of fulminant disseminated infection with Toxoplasma after liver transplantation. Despite numerous diagnostic studies including open lung biopsy, toxoplasmosis was diagnosed only at the time of autopsy and involved the brain, spinal cord, pituitary gland, lungs, and heart. Toxoplasmosis should be considered in the differential diagnosis of multiorgan failure in the early period after liver transplantation. If mismatched serologies could be identified then clinical suspicion might be higher and prophylactic or empirical therapy could be instituted. The United Network for Organ Sharing (Richmond, VA) should consider including serology for Toxoplasma in the testing of donors.

Original languageEnglish (US)
Pages (from-to)511-515
Number of pages5
JournalClinical Infectious Diseases
Volume21
Issue number3
DOIs
StatePublished - Jan 1 1995

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Toxoplasmosis
Toxoplasma
Liver Transplantation
Serology
Lung
Immunocompromised Host
Pituitary Gland
Infection
Autopsy
Spinal Cord
Acquired Immunodeficiency Syndrome
Differential Diagnosis
Tissue Donors
Transplants
Biopsy
Brain
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Mayes, J. T., O’ Connor, B. J., Avery, R., Castellani, W., & Carey, W. (1995). Transmission of toxoplasma gondii infection by liver transplantation. Clinical Infectious Diseases, 21(3), 511-515. https://doi.org/10.1093/clinids/21.3.511
Mayes, James T. ; O’ Connor, Barry J. ; Avery, Robin ; Castellani, William ; Carey, William. / Transmission of toxoplasma gondii infection by liver transplantation. In: Clinical Infectious Diseases. 1995 ; Vol. 21, No. 3. pp. 511-515.
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Mayes, JT, O’ Connor, BJ, Avery, R, Castellani, W & Carey, W 1995, 'Transmission of toxoplasma gondii infection by liver transplantation', Clinical Infectious Diseases, vol. 21, no. 3, pp. 511-515. https://doi.org/10.1093/clinids/21.3.511

Transmission of toxoplasma gondii infection by liver transplantation. / Mayes, James T.; O’ Connor, Barry J.; Avery, Robin; Castellani, William; Carey, William.

In: Clinical Infectious Diseases, Vol. 21, No. 3, 01.01.1995, p. 511-515.

Research output: Contribution to journalArticle

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