Transplantation of Bioprinted Tissues and Organs: Technical and Clinical Challenges and Future Perspectives

Dino J. Ravnic, Ashley N. Leberfinger, Srinivas V. Koduru, Monika Hospodiuk, Kazim K. Moncal, Pallab Datta, Madhuri Dey, Elias Rizk, Ibrahim T. Ozbolat

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Three-dimensional (3D) bioprinting is a revolutionary technology in building living tissues and organs with precise anatomic control and cellular composition. Despite the great progress in bioprinting research, there has yet to be any clinical translation due to current limitations in building human-scale constructs, which are vascularized and readily implantable. In this article, we review the current limitations and challenges in 3D bioprinting, including in situ techniques, which are one of several clinical translational models to facilitate the application of this technology from bench to bedside. A detailed discussion is made on the technical barriers in the fabrication of scalable constructs that are vascularized, autologous, functional, implantable, cost-effective, and ethically feasible. Clinical considerations for implantable bioprinted tissues are further expounded toward the correction of end-stage organ dysfunction and composite tissue deficits.

Original languageEnglish (US)
Pages (from-to)48-58
Number of pages11
JournalAnnals of surgery
Volume266
Issue number1
DOIs
StatePublished - 2017

All Science Journal Classification (ASJC) codes

  • Surgery

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