Transport of semiconductor nanocrystals by kinesin molecular motors

Gayatri Muthukrishnan, Benjamin M. Hutchins, Mary Elizabeth Williams, William O. Hancock

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

The synthesis and functionalization of quantum dots with active kinesin biomolecular motors and transportation of these dots along immobilized microtubules, was investigated. Quantum-dot cores are synthesized in an organic phase and usually with cytotoxic compounds, so for biological applications the cores need to be protected and transferred to an aqueous phase by coating with shell. The conjugation of quantum dots to motors through biotin-avidin leads to the utilization of the semiconductor nanaocrystals as bright and robust fluorophores to track conventional kinesin movement along cytoskeletal filaments. The results show that the nanoclusters can be used to investigate bidirectional transport by motors and co-assembly of heterogeneous particles.

Original languageEnglish (US)
Pages (from-to)626-630
Number of pages5
JournalSmall
Volume2
Issue number5
DOIs
StatePublished - May 1 2006

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Engineering (miscellaneous)
  • Biomaterials
  • Medicine(all)

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