Transpulmonary pressure gradient verifies pulmonary hypertension is initiated by increased arterial resistance in broilers

A. G. Lorenzoni, N. B. Anthony, R. F. Wideman

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Previous hemodynamic evaluations demonstrated that pulmonary arterial pressure (PAP) is higher in broilers that are susceptible to pulmonary hypertension syndrome (PHS, ascites) than in broilers that are resistant to PHS. We compared key pulmonary hemodynamic parameters in broilers from PHS-susceptible and PHS-resistant lines (selected for 12 generations under hypobaric hypoxia) and in broilers from a relaxed (control) line. In experiment 1 the PAP was measured in male broilers in which a flow probe positioned on one pulmonary artery permitted the determination of cardiac output and pulmonary vascular resistance (PVR). The PAP and relative PVR were higher in susceptible broilers than in relaxed and resistant broilers, whereas absolute and relative cardiac output did not differ between lines. In experiment 2 male and female broilers from the 3 lines were catheterized to measure pressures in the wing vein, right atrium, right ventricle, pulmonary artery, and pulmonary veins (WP, wedge pressure). The transpulmonary pressure gradient (TPG) was calculated as (PAP-WP), with PAP quantifying precapillary pressure and WP approximating postcapillary pulmonary venous pressure. When compared with resistant and relaxed broilers, PAP values in susceptible broilers were ≥10 mmHg higher, TPG values were ≥8 mmHg higher, and WP values were ≤2 mmHg higher, regardless of sex. The combined hemodynamic criteria (elevated PAP and PVR combined with a proportionally elevated TPG) demonstrate that susceptibility to PHS can be attributed primarily to pulmonary arterial hypertension associated with increased precapillary (arteriole) resistance rather than to pulmonary venous hypertension caused by elevated postcapillary (venous and left atrial) resistance.

Original languageEnglish (US)
Pages (from-to)125-132
Number of pages8
JournalPoultry science
Volume87
Issue number1
DOIs
StatePublished - Jan 1 2008

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hypertension
broiler chickens
lungs
hemodynamics
blood vessels
pulmonary artery
cardiac output
ascites
hypoxia

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

Cite this

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abstract = "Previous hemodynamic evaluations demonstrated that pulmonary arterial pressure (PAP) is higher in broilers that are susceptible to pulmonary hypertension syndrome (PHS, ascites) than in broilers that are resistant to PHS. We compared key pulmonary hemodynamic parameters in broilers from PHS-susceptible and PHS-resistant lines (selected for 12 generations under hypobaric hypoxia) and in broilers from a relaxed (control) line. In experiment 1 the PAP was measured in male broilers in which a flow probe positioned on one pulmonary artery permitted the determination of cardiac output and pulmonary vascular resistance (PVR). The PAP and relative PVR were higher in susceptible broilers than in relaxed and resistant broilers, whereas absolute and relative cardiac output did not differ between lines. In experiment 2 male and female broilers from the 3 lines were catheterized to measure pressures in the wing vein, right atrium, right ventricle, pulmonary artery, and pulmonary veins (WP, wedge pressure). The transpulmonary pressure gradient (TPG) was calculated as (PAP-WP), with PAP quantifying precapillary pressure and WP approximating postcapillary pulmonary venous pressure. When compared with resistant and relaxed broilers, PAP values in susceptible broilers were ≥10 mmHg higher, TPG values were ≥8 mmHg higher, and WP values were ≤2 mmHg higher, regardless of sex. The combined hemodynamic criteria (elevated PAP and PVR combined with a proportionally elevated TPG) demonstrate that susceptibility to PHS can be attributed primarily to pulmonary arterial hypertension associated with increased precapillary (arteriole) resistance rather than to pulmonary venous hypertension caused by elevated postcapillary (venous and left atrial) resistance.",
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Transpulmonary pressure gradient verifies pulmonary hypertension is initiated by increased arterial resistance in broilers. / Lorenzoni, A. G.; Anthony, N. B.; Wideman, R. F.

In: Poultry science, Vol. 87, No. 1, 01.01.2008, p. 125-132.

Research output: Contribution to journalArticle

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T1 - Transpulmonary pressure gradient verifies pulmonary hypertension is initiated by increased arterial resistance in broilers

AU - Lorenzoni, A. G.

AU - Anthony, N. B.

AU - Wideman, R. F.

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