Treadmill exercise in calves implanted with the AbioCor replacement heart

Benjamin B. Chiang, George M. Pantalos, Patricia Cerrito, Karla Stevens, Karen Lott, Laura Lott, Steven Etoch, Laman A. Gray, Robert Dowling

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of this study was to evaluate the function of the AbioCor artificial heart implanted in calves that underwent treadmill exercise testing and to investigate the cardiovascular and metabolic responses during exercise. Six calves were implanted with the AbioCor. One week after surgery, exercise training was undertaken and animals were put on a treadmill at a speed of 0.5-1.0 mph, with the AbioCor operating at the maximum heart rate of 150 beats per minute. During exercise, the left and right atrial pressures were significantly increased (p < 0.05). Oxygen consumption was significantly elevated (p < 0.05). Lactate levels did not significantly increase (p > 0.05). The index of metabolic adequacy remained higher than 2.0, indicating that there was no substantial transition to anaerobic metabolism during exercise. There was an increased extraction of oxygen during exercise to meet the increased energy demands. Our study demonstrated that animals implanted with the AbioCor heart were able to maintain aerobic metabolism during low levels of exercise testing.

Original languageEnglish (US)
Pages (from-to)589-593
Number of pages5
JournalASAIO Journal
Volume49
Issue number5
DOIs
StatePublished - Sep 1 2003

Fingerprint

Exercise equipment
Metabolism
Animals
Anaerobiosis
Artificial heart
Artificial Heart
Atrial Pressure
Testing
Surgery
Heart Rate
Exercise
Oxygen

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Chiang, B. B., Pantalos, G. M., Cerrito, P., Stevens, K., Lott, K., Lott, L., ... Dowling, R. (2003). Treadmill exercise in calves implanted with the AbioCor replacement heart. ASAIO Journal, 49(5), 589-593. https://doi.org/10.1097/01.MAT.0000084106.25889.FE
Chiang, Benjamin B. ; Pantalos, George M. ; Cerrito, Patricia ; Stevens, Karla ; Lott, Karen ; Lott, Laura ; Etoch, Steven ; Gray, Laman A. ; Dowling, Robert. / Treadmill exercise in calves implanted with the AbioCor replacement heart. In: ASAIO Journal. 2003 ; Vol. 49, No. 5. pp. 589-593.
@article{32474e5abfd341acb7631e40ffb0ca8e,
title = "Treadmill exercise in calves implanted with the AbioCor replacement heart",
abstract = "The aim of this study was to evaluate the function of the AbioCor artificial heart implanted in calves that underwent treadmill exercise testing and to investigate the cardiovascular and metabolic responses during exercise. Six calves were implanted with the AbioCor. One week after surgery, exercise training was undertaken and animals were put on a treadmill at a speed of 0.5-1.0 mph, with the AbioCor operating at the maximum heart rate of 150 beats per minute. During exercise, the left and right atrial pressures were significantly increased (p < 0.05). Oxygen consumption was significantly elevated (p < 0.05). Lactate levels did not significantly increase (p > 0.05). The index of metabolic adequacy remained higher than 2.0, indicating that there was no substantial transition to anaerobic metabolism during exercise. There was an increased extraction of oxygen during exercise to meet the increased energy demands. Our study demonstrated that animals implanted with the AbioCor heart were able to maintain aerobic metabolism during low levels of exercise testing.",
author = "Chiang, {Benjamin B.} and Pantalos, {George M.} and Patricia Cerrito and Karla Stevens and Karen Lott and Laura Lott and Steven Etoch and Gray, {Laman A.} and Robert Dowling",
year = "2003",
month = "9",
day = "1",
doi = "10.1097/01.MAT.0000084106.25889.FE",
language = "English (US)",
volume = "49",
pages = "589--593",
journal = "ASAIO Journal",
issn = "1058-2916",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

Chiang, BB, Pantalos, GM, Cerrito, P, Stevens, K, Lott, K, Lott, L, Etoch, S, Gray, LA & Dowling, R 2003, 'Treadmill exercise in calves implanted with the AbioCor replacement heart', ASAIO Journal, vol. 49, no. 5, pp. 589-593. https://doi.org/10.1097/01.MAT.0000084106.25889.FE

Treadmill exercise in calves implanted with the AbioCor replacement heart. / Chiang, Benjamin B.; Pantalos, George M.; Cerrito, Patricia; Stevens, Karla; Lott, Karen; Lott, Laura; Etoch, Steven; Gray, Laman A.; Dowling, Robert.

In: ASAIO Journal, Vol. 49, No. 5, 01.09.2003, p. 589-593.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Treadmill exercise in calves implanted with the AbioCor replacement heart

AU - Chiang, Benjamin B.

AU - Pantalos, George M.

AU - Cerrito, Patricia

AU - Stevens, Karla

AU - Lott, Karen

AU - Lott, Laura

AU - Etoch, Steven

AU - Gray, Laman A.

AU - Dowling, Robert

PY - 2003/9/1

Y1 - 2003/9/1

N2 - The aim of this study was to evaluate the function of the AbioCor artificial heart implanted in calves that underwent treadmill exercise testing and to investigate the cardiovascular and metabolic responses during exercise. Six calves were implanted with the AbioCor. One week after surgery, exercise training was undertaken and animals were put on a treadmill at a speed of 0.5-1.0 mph, with the AbioCor operating at the maximum heart rate of 150 beats per minute. During exercise, the left and right atrial pressures were significantly increased (p < 0.05). Oxygen consumption was significantly elevated (p < 0.05). Lactate levels did not significantly increase (p > 0.05). The index of metabolic adequacy remained higher than 2.0, indicating that there was no substantial transition to anaerobic metabolism during exercise. There was an increased extraction of oxygen during exercise to meet the increased energy demands. Our study demonstrated that animals implanted with the AbioCor heart were able to maintain aerobic metabolism during low levels of exercise testing.

AB - The aim of this study was to evaluate the function of the AbioCor artificial heart implanted in calves that underwent treadmill exercise testing and to investigate the cardiovascular and metabolic responses during exercise. Six calves were implanted with the AbioCor. One week after surgery, exercise training was undertaken and animals were put on a treadmill at a speed of 0.5-1.0 mph, with the AbioCor operating at the maximum heart rate of 150 beats per minute. During exercise, the left and right atrial pressures were significantly increased (p < 0.05). Oxygen consumption was significantly elevated (p < 0.05). Lactate levels did not significantly increase (p > 0.05). The index of metabolic adequacy remained higher than 2.0, indicating that there was no substantial transition to anaerobic metabolism during exercise. There was an increased extraction of oxygen during exercise to meet the increased energy demands. Our study demonstrated that animals implanted with the AbioCor heart were able to maintain aerobic metabolism during low levels of exercise testing.

UR - http://www.scopus.com/inward/record.url?scp=0141590372&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141590372&partnerID=8YFLogxK

U2 - 10.1097/01.MAT.0000084106.25889.FE

DO - 10.1097/01.MAT.0000084106.25889.FE

M3 - Article

C2 - 14524570

AN - SCOPUS:0141590372

VL - 49

SP - 589

EP - 593

JO - ASAIO Journal

JF - ASAIO Journal

SN - 1058-2916

IS - 5

ER -

Chiang BB, Pantalos GM, Cerrito P, Stevens K, Lott K, Lott L et al. Treadmill exercise in calves implanted with the AbioCor replacement heart. ASAIO Journal. 2003 Sep 1;49(5):589-593. https://doi.org/10.1097/01.MAT.0000084106.25889.FE