Treatment of phantom limb pain syndrome by tisanidin

Ya M. Vorobeichik, M. L. Kukushkin, V. K. Reshetnyak, A. M. Ovechkin, A. V. Gnezdilov

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The authors carried out estimation of analgetic effect of tisanidin by double blind test in patients with phantom limb pain syndrome. 14 patients took the medicine in a dose of 12 mg/day and 5 patients took placebo at the same dose. Characteristics and intensity of pain were estimated in accordance with McGill pain questionnaire and visual analogue scale. Pain possessed more than one sensory characteristics in the majority of patients. Tisanidin had a significant analgetic influence on all type of phantom limb pain: "neuralgic" - acute, shooting, transitory, "causalgic" -hot, burning, searing, "cramping" pain. Pain sensation did not decrease only in one of 14 patients treated with tisanidin. The authors explain the effectivity of the drug for treatment of phantom limb pain of different sensory modality by variety of the mechanisms of its therapeutic action, the capacity to decrease the releasing of exitatory neurotransmitter amino acids and the influence on α2-adrenoceptors.

Original languageEnglish (US)
Pages (from-to)36-39
Number of pages4
JournalZhurnal Nevropatolgii i Psikhiatrii im. S S Korsakova
Volume97
Issue number3
StatePublished - Dec 1 1997

Fingerprint

Phantom Limb
Pain
Therapeutics
Pain Measurement
Visual Analog Scale
Adrenergic Receptors
Neurotransmitter Agents
Placebos
Medicine
Amino Acids
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Vorobeichik, Y. M., Kukushkin, M. L., Reshetnyak, V. K., Ovechkin, A. M., & Gnezdilov, A. V. (1997). Treatment of phantom limb pain syndrome by tisanidin. Zhurnal Nevropatolgii i Psikhiatrii im. S S Korsakova, 97(3), 36-39.
Vorobeichik, Ya M. ; Kukushkin, M. L. ; Reshetnyak, V. K. ; Ovechkin, A. M. ; Gnezdilov, A. V. / Treatment of phantom limb pain syndrome by tisanidin. In: Zhurnal Nevropatolgii i Psikhiatrii im. S S Korsakova. 1997 ; Vol. 97, No. 3. pp. 36-39.
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Vorobeichik, YM, Kukushkin, ML, Reshetnyak, VK, Ovechkin, AM & Gnezdilov, AV 1997, 'Treatment of phantom limb pain syndrome by tisanidin', Zhurnal Nevropatolgii i Psikhiatrii im. S S Korsakova, vol. 97, no. 3, pp. 36-39.

Treatment of phantom limb pain syndrome by tisanidin. / Vorobeichik, Ya M.; Kukushkin, M. L.; Reshetnyak, V. K.; Ovechkin, A. M.; Gnezdilov, A. V.

In: Zhurnal Nevropatolgii i Psikhiatrii im. S S Korsakova, Vol. 97, No. 3, 01.12.1997, p. 36-39.

Research output: Contribution to journalArticle

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Vorobeichik YM, Kukushkin ML, Reshetnyak VK, Ovechkin AM, Gnezdilov AV. Treatment of phantom limb pain syndrome by tisanidin. Zhurnal Nevropatolgii i Psikhiatrii im. S S Korsakova. 1997 Dec 1;97(3):36-39.