Treatment of Sexual Precocity by Removal of a Luteinizing Hormone—Releasing Hormone Secreting Hamartoma

Robert A. Price, Peter Lee, A. Leland Albright, Oline K. Ronnekleiv

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

A 1-year-old infant was initially seen with precocious puberty that progressed rapidly and was associated with episodic gonadotropin release. A computed tomographic metrizamide cisternogram showed a pedunculated mass below the tuber cinereum; the mass was resected. His pubertal development regressed, his accelerated growth ceased, and his hormone levels returned to the normal prepubertal range. Immunocytochemical studies of the tissue demonstrated luteinizing hormone—releasing hormone (LHRH) granules in the perikaryon of neurons and axons in the hamartoma and axons connecting the hamartoma to the tuber cinereum. These data suggest that such lesions cause pubertal development by stimulating gonadotropin secretion via episodic release of LHRH. If such lesions are pedunculated, operative resection may be the treatment of choice.

Original languageEnglish (US)
Pages (from-to)2247-2249
Number of pages3
JournalJAMA: The Journal of the American Medical Association
Volume251
Issue number17
DOIs
StatePublished - May 4 1984

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Tuber Cinereum
Hamartoma
Luteinizing Hormone
Gonadotropins
Axons
Metrizamide
Precocious Puberty
Growth Hormone
Reference Values
Neurons
Therapeutics
Sexual precocity

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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Treatment of Sexual Precocity by Removal of a Luteinizing Hormone—Releasing Hormone Secreting Hamartoma. / Price, Robert A.; Lee, Peter; Albright, A. Leland; Ronnekleiv, Oline K.

In: JAMA: The Journal of the American Medical Association, Vol. 251, No. 17, 04.05.1984, p. 2247-2249.

Research output: Contribution to journalArticle

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