Treatment status predicts differential prefrontal cortical responses to alcohol and natural reinforcer cues among alcohol dependent individuals

Scott Bunce, Kurtulus Izzetoglu, Meltem Izzetoglu, Hasan Ayaz, Kambiz Pourrezaei, Banu Onaral

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Abstract

This study used functional near-infrared spectroscopy (fNIRs) to test the hypothesis that non-treatment seeking alcohol-dependent participants (NTSA) would show greater response in dorsolateral prefrontal cortex (DLPFC) to alcohol cues than recovering alcoholics (RA; sober 90-180 days) or social drinkers. Opposite predictions were made for responses to natural reward cues. NTSA (n=4), RA (n=6), and social drinkers (n=4) were exposed to alcohol and natural reward cues while being monitored with fNIRs. Results confirmed enhanced responses to alcohol cues among NTSA vs. RA in right middle frontal gyrus. The opposite effect (RA>NTSA) was found in response to natural reward cues. Neural responses to alcohol and natural reward cues were negatively correlated in right DLPFC. Real-time craving ratings were positively correlated with greater neural response to alcohol cues. Differential responses to drug and natural reward cues suggest that a psychological mechanism related to treatment status may modulate drug cue responses in DLPFC.

Original languageEnglish (US)
Title of host publicationAdvances in Brain Inspired Cognitive Systems - 5th International Conference, BICS 2012, Proceedings
Pages183-191
Number of pages9
DOIs
StatePublished - Aug 27 2012
Event5th International Conference on Advances in Brain Inspired Cognitive Systems, BICS 2012 - Shenyang, China
Duration: Jul 11 2012Jul 14 2012

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume7366 LNAI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other5th International Conference on Advances in Brain Inspired Cognitive Systems, BICS 2012
CountryChina
CityShenyang
Period7/11/127/14/12

All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • Computer Science(all)

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