Trending of impedance-monitored cardiac variables: Method and statistical power analysis of 100 control studies in a pediatric intensive care unit

J. J. Mickell, Steven Lucking, F. C. Chaten, E. S. Young

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The NCCOM3-R6 monitor continuously monitors cardiac output and five other cardiovascular variables from the thoracic electrical bioimpedance signal. We averaged data over 5-min intervals for 130 min in 100 control studies in 40 pediatric ICU patients, age 0.04 to 20.39 yr (median 1.39) and weighing 2.0 to 59.5 kg (median 8.8). For individual studies, 99% of the 5-min averages of cardiac output fell within ± 44% of the baseline cardiac output for that study. Normal ranges were somewhat narrower for the other five variables. When we averaged data for 100 studies, 5-min interval observations for each variable did not deviate from baseline over a 2-h period (p > .70). With a sample size of 100 studies, we could detect a change in cardiac output of ± 5% at the p < .005 level with a power of 0.95. We conclude that with a sufficiently large sample size, studies employing the NCCOM3 can detect clinically significant cardiovascular changes due to pharmacologic or procedural stressors.

Original languageEnglish (US)
Pages (from-to)645-650
Number of pages6
JournalCritical Care Medicine
Volume18
Issue number6
DOIs
StatePublished - Jan 1 1990

Fingerprint

Pediatric Intensive Care Units
Electric Impedance
Cardiac Output
Sample Size
Reference Values
Thorax
Pediatrics

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

Cite this

@article{e14d6a2961654b8784702f0fbb3653ad,
title = "Trending of impedance-monitored cardiac variables: Method and statistical power analysis of 100 control studies in a pediatric intensive care unit",
abstract = "The NCCOM3-R6 monitor continuously monitors cardiac output and five other cardiovascular variables from the thoracic electrical bioimpedance signal. We averaged data over 5-min intervals for 130 min in 100 control studies in 40 pediatric ICU patients, age 0.04 to 20.39 yr (median 1.39) and weighing 2.0 to 59.5 kg (median 8.8). For individual studies, 99{\%} of the 5-min averages of cardiac output fell within ± 44{\%} of the baseline cardiac output for that study. Normal ranges were somewhat narrower for the other five variables. When we averaged data for 100 studies, 5-min interval observations for each variable did not deviate from baseline over a 2-h period (p > .70). With a sample size of 100 studies, we could detect a change in cardiac output of ± 5{\%} at the p < .005 level with a power of 0.95. We conclude that with a sufficiently large sample size, studies employing the NCCOM3 can detect clinically significant cardiovascular changes due to pharmacologic or procedural stressors.",
author = "Mickell, {J. J.} and Steven Lucking and Chaten, {F. C.} and Young, {E. S.}",
year = "1990",
month = "1",
day = "1",
doi = "10.1097/00003246-199006000-00014",
language = "English (US)",
volume = "18",
pages = "645--650",
journal = "Critical Care Medicine",
issn = "0090-3493",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

Trending of impedance-monitored cardiac variables : Method and statistical power analysis of 100 control studies in a pediatric intensive care unit. / Mickell, J. J.; Lucking, Steven; Chaten, F. C.; Young, E. S.

In: Critical Care Medicine, Vol. 18, No. 6, 01.01.1990, p. 645-650.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Trending of impedance-monitored cardiac variables

T2 - Method and statistical power analysis of 100 control studies in a pediatric intensive care unit

AU - Mickell, J. J.

AU - Lucking, Steven

AU - Chaten, F. C.

AU - Young, E. S.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The NCCOM3-R6 monitor continuously monitors cardiac output and five other cardiovascular variables from the thoracic electrical bioimpedance signal. We averaged data over 5-min intervals for 130 min in 100 control studies in 40 pediatric ICU patients, age 0.04 to 20.39 yr (median 1.39) and weighing 2.0 to 59.5 kg (median 8.8). For individual studies, 99% of the 5-min averages of cardiac output fell within ± 44% of the baseline cardiac output for that study. Normal ranges were somewhat narrower for the other five variables. When we averaged data for 100 studies, 5-min interval observations for each variable did not deviate from baseline over a 2-h period (p > .70). With a sample size of 100 studies, we could detect a change in cardiac output of ± 5% at the p < .005 level with a power of 0.95. We conclude that with a sufficiently large sample size, studies employing the NCCOM3 can detect clinically significant cardiovascular changes due to pharmacologic or procedural stressors.

AB - The NCCOM3-R6 monitor continuously monitors cardiac output and five other cardiovascular variables from the thoracic electrical bioimpedance signal. We averaged data over 5-min intervals for 130 min in 100 control studies in 40 pediatric ICU patients, age 0.04 to 20.39 yr (median 1.39) and weighing 2.0 to 59.5 kg (median 8.8). For individual studies, 99% of the 5-min averages of cardiac output fell within ± 44% of the baseline cardiac output for that study. Normal ranges were somewhat narrower for the other five variables. When we averaged data for 100 studies, 5-min interval observations for each variable did not deviate from baseline over a 2-h period (p > .70). With a sample size of 100 studies, we could detect a change in cardiac output of ± 5% at the p < .005 level with a power of 0.95. We conclude that with a sufficiently large sample size, studies employing the NCCOM3 can detect clinically significant cardiovascular changes due to pharmacologic or procedural stressors.

UR - http://www.scopus.com/inward/record.url?scp=0025330258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025330258&partnerID=8YFLogxK

U2 - 10.1097/00003246-199006000-00014

DO - 10.1097/00003246-199006000-00014

M3 - Article

C2 - 2344756

AN - SCOPUS:0025330258

VL - 18

SP - 645

EP - 650

JO - Critical Care Medicine

JF - Critical Care Medicine

SN - 0090-3493

IS - 6

ER -