Trends in pharmacotherapy for neonatal hypotension

Danielle R. Rios, Brady S. Moffett, Jeffrey R. Kaiser

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Study design We queried the Pediatric Health Information System database for all infants ≥28 days with a diagnosis code for hypotension that were discharged between January 2001 and December 2012. Patients were excluded if they had complex congenital heart disease or cardiac surgery, sepsis or meningitis, or had extracorporeal membrane oxygenation. We determined trends in pharmacotherapy for hypotension in all infants and ELBW infants, an especially vulnerable group.

Results A total of 8019 hypotensive infants met study criteria. The 2 most prescribed medications were dopamine (65.3%) and dobutamine (19.9%). For 1487 hypotensive ELBW infants, the 2 most prescribed medications were dopamine (83.4%) and hydrocortisone (33%). During the study period, the use of dobutamine decreased, and hydrocortisone and vasopressin use increased for all infants and for ELBW infants.

Conclusions Treatment of neonatal hypotension varies widely between institutions and individual practitioners, and pharmacotherapy for neonatal hypotension has changed over the past decade. Although dopamine and dobutamine were the most frequently used agents, their use has declined and the uses of hydrocortisone and vasopressin have increased.

Objective To determine trends in pharmacotherapy for neonatal hypotension in all infants and in extremely low birth weight (ELBW, birth weight 300-1000 g) infants.

Original languageEnglish (US)
Pages (from-to)697-701.e1
JournalJournal of Pediatrics
Volume165
Issue number4
DOIs
StatePublished - Oct 1 2014

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Hypotension
Drug Therapy
Dobutamine
Hydrocortisone
Dopamine
Vasopressins
Thoracic Surgery
Extremely Low Birth Weight Infant
Health Information Systems
Extracorporeal Membrane Oxygenation
Meningitis
Birth Weight
Heart Diseases
Sepsis
Databases
Pediatrics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Rios, Danielle R. ; Moffett, Brady S. ; Kaiser, Jeffrey R. / Trends in pharmacotherapy for neonatal hypotension. In: Journal of Pediatrics. 2014 ; Vol. 165, No. 4. pp. 697-701.e1.
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Trends in pharmacotherapy for neonatal hypotension. / Rios, Danielle R.; Moffett, Brady S.; Kaiser, Jeffrey R.

In: Journal of Pediatrics, Vol. 165, No. 4, 01.10.2014, p. 697-701.e1.

Research output: Contribution to journalArticle

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AU - Kaiser, Jeffrey R.

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