Trends of Acute Ischemic Stroke Reperfusion Therapies from 2012 to 2016 in the United States

Nandakumar Nagaraja, Paul S. Kubilis, Brian L. Hoh, Christina A. Wilson, Anna Y. Khanna, Adam G. Kelly

Research output: Contribution to journalArticlepeer-review


Background: American Heart Association/American Stroke Association guidelines recommend endovascular stroke therapy (EST) with recombinant tissue plasminogen activator (rt-PA) for eligible patients in acute ischemic stroke (AIS). Using the National Inpatient Sample database, we evaluated trends in treatment with rt-PA and EST for AIS and their outcomes. Methods: This is a cross-sectional observational study of patients with AIS admitted in US hospitals from 2012 to 2016. Patients were grouped into those who received rt-PA alone, EST alone, and rtPA+EST. Survey statistical procedures were performed. Multivariable regression analysis with pairwise comparisons of each treatment group with no treatment group was performed for discharge outcomes. Results: The study included 2,290,520 patients with AIS with the mean age of 70.46 years. Treatment rates increased from 2012 to 2016 for rt-PA by 7% per year (5.86%–7.67%, odds ratio [OR] = 1.07, 95% confidence interval [CI]: 1.05–1.08) and EST by 38% per year (0.55%–1.75%, OR = 1.38, 95% CI: 1.31–1.45) but not rt-PA+EST (0.54%–0.57%, OR = 1.04, 95% CI: 0.99–1.08). The mean length of stay reduced from 2012 to 2016 for rt-PA (6.07–4.91 days, P < 0.0001) and rt-PA+EST (9.19–7.10 days, P = 0.0067) but not for EST (9.61–8.51 days, P = 0.5074). The odds of patients discharged home increased by 8%, 9%, and 15% among patients who received rt-PA alone, EST alone, and rt-PA+EST, respectively, compared with no treatment group. Conclusion: The utilization of rt-PA alone and EST alone increased but that of rt-PA+EST remained unchanged from 2012 to 2016 in the National Inpatient Sample.

Original languageEnglish (US)
Pages (from-to)e621-e630
JournalWorld neurosurgery
StatePublished - Jun 2021

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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