Triazole cycloaddition as a general route for functionalization of Au nanoparticles

David A. Fleming, Christopher J. Thode, Mary Elizabeth Williams

Research output: Contribution to journalArticlepeer-review

158 Scopus citations

Abstract

Triazole formation by 1,3-dipolar cycloaddition reactions, "click" chemistry, has been used to functionalize the surfaces of Au nanoparticles. Au particle samples were first synthesized through standard procedures, the methyl-terminated chains partially exchanged with ω-bromo-functionalized thiol, and the Br termini converted to azides by reaction with NaN 3. These particles were then reacted with a series of alkynyl derivatized small molecules in nonpolar solutions, which led to their attachment through the formation of a 1,2,3-triazole ring, confirmed through NMR and IR spectroscopies. Click reactions were used to impart chemical functionality to the Au particles, which is assessed using fluorescence spectroscopy and cyclic voltammetry.

Original languageEnglish (US)
Pages (from-to)2327-2334
Number of pages8
JournalChemistry of Materials
Volume18
Issue number9
DOIs
StatePublished - May 2 2006

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry

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