Trigeminal neuralgia: Mechanisms of treatment

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Background: Mechanisms of the surgical treatment of trigeminal neuralgia are considered. Results: Trigeminal neuralgia is effectively treated by microvascular decompression (MVD) and other surgical procedures. These procedures often cause reactivation of herpes simplex virus (HSV), which is latent in trigeminal ganglion neurons. Conclusion: MVD and other surgical procedures alter ganglion neuron transcription, as indicated by HSV reactivation. Controlled injury of the trigeminal root-ganglion probably occurs with the disparate surgical procedures, and this is likely the means of their effectiveness.

Original languageEnglish (US)
Pages (from-to)17-19
Number of pages3
JournalNeurology
Volume51
Issue number1
DOIs
StatePublished - Jul 1998

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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