Tritium labelled (±)‐10‐[2‐(1‐methyl‐2‐piperidinyl)ethyl]‐2‐(methyl‐mercapto)‐[3‐3H(n)]phenothiazine (thioridazine)

Steven D. Wyrick, Richard Mailman, Diane M. Niedzwiecki

Research output: Contribution to journalArticle

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Abstract

The antipsychotic drug, thioridazine, differs from more classical antipsychotic drugs with respect to both some atypical psychopharmacological characteristics and to the critical involvement of active metabolites in its pharmacology. Tritium labelled thioridazine has been prepared in our laboratory by palladium catalyzed reduction of an aryl brominated precursor using carrier free tritium gas in THF. The product is labelled in the 3‐position of the phenothiazine ring system and a specifie activity of 12 Ci/mmole was obtained.

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume23
Issue number1
DOIs
StatePublished - Jan 1 1986

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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