Tritium labelled (±)‐10‐[2‐(1‐methyl‐2‐piperidinyl)ethyl]‐2‐(methyl‐mercapto)‐[3‐3H(n)]phenothiazine (thioridazine)

Steven D. Wyrick, Richard Mailman, Diane M. Niedzwiecki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The antipsychotic drug, thioridazine, differs from more classical antipsychotic drugs with respect to both some atypical psychopharmacological characteristics and to the critical involvement of active metabolites in its pharmacology. Tritium labelled thioridazine has been prepared in our laboratory by palladium catalyzed reduction of an aryl brominated precursor using carrier free tritium gas in THF. The product is labelled in the 3‐position of the phenothiazine ring system and a specifie activity of 12 Ci/mmole was obtained.

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume23
Issue number1
DOIs
StatePublished - Jan 1 1986

Fingerprint

Thioridazine
Tritium
Antipsychotic Agents
Palladium
Metabolites
Gases
Pharmacology
phenothiazine

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

Cite this

@article{d9f42516974445058fb9f2b152550c89,
title = "Tritium labelled (±)‐10‐[2‐(1‐methyl‐2‐piperidinyl)ethyl]‐2‐(methyl‐mercapto)‐[3‐3H(n)]phenothiazine (thioridazine)",
abstract = "The antipsychotic drug, thioridazine, differs from more classical antipsychotic drugs with respect to both some atypical psychopharmacological characteristics and to the critical involvement of active metabolites in its pharmacology. Tritium labelled thioridazine has been prepared in our laboratory by palladium catalyzed reduction of an aryl brominated precursor using carrier free tritium gas in THF. The product is labelled in the 3‐position of the phenothiazine ring system and a specifie activity of 12 Ci/mmole was obtained.",
author = "Wyrick, {Steven D.} and Richard Mailman and Niedzwiecki, {Diane M.}",
year = "1986",
month = "1",
day = "1",
doi = "10.1002/jlcr.2580230112",
language = "English (US)",
volume = "23",
pages = "95--101",
journal = "Journal of Labelled Compounds and Radiopharmaceuticals",
issn = "0362-4803",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

TY - JOUR

T1 - Tritium labelled (±)‐10‐[2‐(1‐methyl‐2‐piperidinyl)ethyl]‐2‐(methyl‐mercapto)‐[3‐3H(n)]phenothiazine (thioridazine)

AU - Wyrick, Steven D.

AU - Mailman, Richard

AU - Niedzwiecki, Diane M.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - The antipsychotic drug, thioridazine, differs from more classical antipsychotic drugs with respect to both some atypical psychopharmacological characteristics and to the critical involvement of active metabolites in its pharmacology. Tritium labelled thioridazine has been prepared in our laboratory by palladium catalyzed reduction of an aryl brominated precursor using carrier free tritium gas in THF. The product is labelled in the 3‐position of the phenothiazine ring system and a specifie activity of 12 Ci/mmole was obtained.

AB - The antipsychotic drug, thioridazine, differs from more classical antipsychotic drugs with respect to both some atypical psychopharmacological characteristics and to the critical involvement of active metabolites in its pharmacology. Tritium labelled thioridazine has been prepared in our laboratory by palladium catalyzed reduction of an aryl brominated precursor using carrier free tritium gas in THF. The product is labelled in the 3‐position of the phenothiazine ring system and a specifie activity of 12 Ci/mmole was obtained.

UR - http://www.scopus.com/inward/record.url?scp=0022657458&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022657458&partnerID=8YFLogxK

U2 - 10.1002/jlcr.2580230112

DO - 10.1002/jlcr.2580230112

M3 - Article

AN - SCOPUS:0022657458

VL - 23

SP - 95

EP - 101

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 1

ER -