TRPC channels in smooth muscle cells

Jose C. Gonzalez-Cobos, Mohamed Trebak

Research output: Contribution to journalReview article

55 Citations (Scopus)

Abstract

Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the gastrointestinal tract. TRPC channels have recently emerged as important players in the control of smooth muscle function. This review will focus on the retrospective analysis of studies proposing contributions of TRPC channels to native calcium entry pathways in smooth muscle and to physiological and pathophysiological responses with emphasis on the vascular system.

Original languageEnglish (US)
Pages (from-to)1023-1039
Number of pages17
JournalFrontiers in Bioscience
Volume15
Issue number3
DOIs
StatePublished - Jun 1 2010

Fingerprint

Transient Receptor Potential Channels
Smooth Muscle Myocytes
Smooth Muscle
Muscle
Cells
Vascular Smooth Muscle
Uterus
Blood Vessels
Gastrointestinal Tract
Cations
Retrospective Studies
Calcium
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Gonzalez-Cobos, Jose C. ; Trebak, Mohamed. / TRPC channels in smooth muscle cells. In: Frontiers in Bioscience. 2010 ; Vol. 15, No. 3. pp. 1023-1039.
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TRPC channels in smooth muscle cells. / Gonzalez-Cobos, Jose C.; Trebak, Mohamed.

In: Frontiers in Bioscience, Vol. 15, No. 3, 01.06.2010, p. 1023-1039.

Research output: Contribution to journalReview article

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