TY - JOUR
T1 - Tuberculosis in medieval and early modern Denmark
T2 - A paleoepidemiological perspective
AU - Dangvard Pedersen, Dorthe
AU - Milner, George R.
AU - Kolmos, Hans Jørn
AU - Boldsen, Jesper Lier
N1 - Funding Information:
Morten S?vs?, Michael Alr? Jensen and Maria Knudsen from Sydvestjyske Museer in Ribe are thanked for assisting with the archaeological information concerning the skeletons. Niels Lynnerup from the Anthropological Collection, Unit of Forensic Anthropology, Department of Forensic Medicine, University of Copenhagen is thanked for granting access to skeletons from the Black Friar cemetery. This research was financed by the Velux foundation through the Ophelia project and the Faculty of Health Sciences, University of Southern Denmark, Odense.
PY - 2019/12
Y1 - 2019/12
N2 - Millions of people worldwide have sickened and died from tuberculosis in recent centuries. Yet for most of human existence, the impact of tuberculosis on society is largely unknown. It is, indeed, unknowable without methods suitable for estimating disease prevalence in skeletal samples. Here such a procedure is applied to medieval and early modern Danish skeletons, and it shows how disease prevalence varied with differences in socioeconomic conditions. The approach is based on sensitivity and specificity estimates from modern skeletons. To augment our understanding of tuberculosis in Danish history, 713 adult skeletons were examined, all from Ribe. Tuberculosis increased from 17% to 40% in the medieval to early modern periods in Ribe. Low status (29%) people were more likely to contract the disease than those of high status (10%). The general model, derived from the modern expression of tuberculosis, fits the early modern sample better than it does the medieval skeletons. Differences in the model's fit indicate the skeletal expression changed over time. Notably, rib lesions increased in frequency from the medieval to early modern periods. The approach developed here can provide insights into host-pathogen relationships and disease expression in future work with tuberculosis and other diseases that affect the skeleton.
AB - Millions of people worldwide have sickened and died from tuberculosis in recent centuries. Yet for most of human existence, the impact of tuberculosis on society is largely unknown. It is, indeed, unknowable without methods suitable for estimating disease prevalence in skeletal samples. Here such a procedure is applied to medieval and early modern Danish skeletons, and it shows how disease prevalence varied with differences in socioeconomic conditions. The approach is based on sensitivity and specificity estimates from modern skeletons. To augment our understanding of tuberculosis in Danish history, 713 adult skeletons were examined, all from Ribe. Tuberculosis increased from 17% to 40% in the medieval to early modern periods in Ribe. Low status (29%) people were more likely to contract the disease than those of high status (10%). The general model, derived from the modern expression of tuberculosis, fits the early modern sample better than it does the medieval skeletons. Differences in the model's fit indicate the skeletal expression changed over time. Notably, rib lesions increased in frequency from the medieval to early modern periods. The approach developed here can provide insights into host-pathogen relationships and disease expression in future work with tuberculosis and other diseases that affect the skeleton.
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U2 - 10.1016/j.ijpp.2018.11.003
DO - 10.1016/j.ijpp.2018.11.003
M3 - Article
C2 - 30522981
AN - SCOPUS:85057523800
VL - 27
SP - 101
EP - 108
JO - International Journal of Paleopathology
JF - International Journal of Paleopathology
SN - 1879-9817
ER -