Tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs

Min Liu; Qin Pan; Fengling Luo; Craig Meyers; Xiao Lian Zhang

doi:10.1007/s11859-013-0885-0

Tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs

Min Liu, Qin Pan, Fengling Luo, Craig Meyers, Xiao Lian Zhang

Research output: Contribution to journal › Article › peer-review

Abstract

Certain carbohydrate antigens of malignantly transformed cells have been identified as markers for the onset of cancer and have become targets for the development of anticancer vaccine therapies. For tumor antigens, many carbohydrate antigens belong to T-independent (TI) antigens. Carbohydrate conjugated to protein carriers can switch TI antigen to a T-dependent (TD) antigen. Attempts to add an innate immune response element (such as Toll-like receptor ligand) to carbohydrate TI-antigens have also been studied. Glycosylation inhibitors or small interfering RNA have also been used for antitumor and/or antiviral agents. This review aims at describing the vast spectrum of tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Wuhan University Journal of Natural Sciences
Volume	18
Issue number	1
DOIs	https://doi.org/10.1007/s11859-013-0885-0
State	Published - Feb 2013

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10.1007/s11859-013-0885-0

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title = "Tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs",

abstract = "Certain carbohydrate antigens of malignantly transformed cells have been identified as markers for the onset of cancer and have become targets for the development of anticancer vaccine therapies. For tumor antigens, many carbohydrate antigens belong to T-independent (TI) antigens. Carbohydrate conjugated to protein carriers can switch TI antigen to a T-dependent (TD) antigen. Attempts to add an innate immune response element (such as Toll-like receptor ligand) to carbohydrate TI-antigens have also been studied. Glycosylation inhibitors or small interfering RNA have also been used for antitumor and/or antiviral agents. This review aims at describing the vast spectrum of tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs.",

author = "Min Liu and Qin Pan and Fengling Luo and Craig Meyers and Zhang, {Xiao Lian}",

note = "Funding Information: Received date: 2012-09-12 Foundation item: Supported by the National Outstanding Youth Foundation of China (81025008), the National Natural Science Foundation of China (30921001, 30800038, 31270176 and 81000714), the National Grand Program on Important Infectious Disease (2012ZX10003002-015), the National Basic Research Program of China (973 Program, 2009CB522507 and 2012CB720604). Biography: LIU Min, female, Lecturer, Ph.D., research direction: glycobiol-ogy and immunology. E-mail: lliumin2002@163.com. LIU Min, PAN Qin, and LUO Fengling contributed equally to this work. † To whom correspondence should be addressed. E-mail: zhangxiaolian@whu. edu.cn.",

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doi = "10.1007/s11859-013-0885-0",

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AU - Liu, Min

AU - Pan, Qin

AU - Luo, Fengling

AU - Meyers, Craig

AU - Zhang, Xiao Lian

N1 - Funding Information: Received date: 2012-09-12 Foundation item: Supported by the National Outstanding Youth Foundation of China (81025008), the National Natural Science Foundation of China (30921001, 30800038, 31270176 and 81000714), the National Grand Program on Important Infectious Disease (2012ZX10003002-015), the National Basic Research Program of China (973 Program, 2009CB522507 and 2012CB720604). Biography: LIU Min, female, Lecturer, Ph.D., research direction: glycobiol-ogy and immunology. E-mail: lliumin2002@163.com. LIU Min, PAN Qin, and LUO Fengling contributed equally to this work. † To whom correspondence should be addressed. E-mail: zhangxiaolian@whu. edu.cn.

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AB - Certain carbohydrate antigens of malignantly transformed cells have been identified as markers for the onset of cancer and have become targets for the development of anticancer vaccine therapies. For tumor antigens, many carbohydrate antigens belong to T-independent (TI) antigens. Carbohydrate conjugated to protein carriers can switch TI antigen to a T-dependent (TD) antigen. Attempts to add an innate immune response element (such as Toll-like receptor ligand) to carbohydrate TI-antigens have also been studied. Glycosylation inhibitors or small interfering RNA have also been used for antitumor and/or antiviral agents. This review aims at describing the vast spectrum of tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs.

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Tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs

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