Tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs

Min Liu, Qin Pan, Fengling Luo, Craig Meyers, Xiao Lian Zhang

Research output: Contribution to journalArticle

Abstract

Certain carbohydrate antigens of malignantly transformed cells have been identified as markers for the onset of cancer and have become targets for the development of anticancer vaccine therapies. For tumor antigens, many carbohydrate antigens belong to T-independent (TI) antigens. Carbohydrate conjugated to protein carriers can switch TI antigen to a T-dependent (TD) antigen. Attempts to add an innate immune response element (such as Toll-like receptor ligand) to carbohydrate TI-antigens have also been studied. Glycosylation inhibitors or small interfering RNA have also been used for antitumor and/or antiviral agents. This review aims at describing the vast spectrum of tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalWuhan University Journal of Natural Sciences
Volume18
Issue number1
DOIs
StatePublished - Feb 11 2013

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All Science Journal Classification (ASJC) codes

  • General

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