Tumor molecular profiling for an individualized approach to the treatment of hepatocellular carcinoma: A patient case study

Kristine Posadas, Anita Ankola, Zhaohai Yang, Nelson S. Yee

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Hepatocellular carcinoma (HCC) is increasing in incidence, and the associated mortality rate remains among the highest. For advanced HCC, sorafenib has been shown to slightly prolong survival, and regorafenib and nivolumab, both recently approved by the United States Food and Drug Administration (FDA), may produce clinical benefits to a limited extent. Systemic chemotherapy has been shown to produce a modest response, but there is no clinically valid biomarker that can be used to predict which patients may benefit. In this case study, we present two patients with metastatic HCC, they received systemic treatment using capecitabine, oxaliplatin, and either bevacizumab or sorafenib. The tumor response to treatment was determined by the progression-free survival (PFS). Molecular profiling of the tumors showed differential expression of biochemical markers and different mutational status of the TP53 and β-catenin (CTNNB1) genes. We hypothesize that the PFS correlates with the tumor molecular profiles, which may be predictive of the therapeutic response to systemic chemotherapy. Further investigation is indicated to correlate tumor biomarkers and treatment responses, with the objective of personalizing the therapies for patients with advanced HCC.

Original languageEnglish (US)
Article number46
JournalBiomedicines
Volume6
Issue number2
DOIs
StatePublished - Jun 1 2018

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Tumor molecular profiling for an individualized approach to the treatment of hepatocellular carcinoma: A patient case study'. Together they form a unique fingerprint.

  • Cite this