Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues

Károly Mészáros; Charles H. Lang; Gregory J. Bagby; John J. Spitzer

doi:10.1016/0006-291X(87)91596-8

Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues

Károly Mészáros, Charles H. Lang, Gregory J. Bagby, John J. Spitzer

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Glucose utilization of different tissues was investigated in vivo by the 2-deoxyglucose tracer technique. After infusion of a non-lethal dose of recombinant human TNF-α (150 μg/kg) to rats, glucose utilization was increased by 80-100% in spleen, liver, kidney, by 60% in skin and by 30-40% in lung and ileum. The largest increase (150%) was observed in the diaphragm. There was no significant change in glucose utilization by skeletal muscles, testis and brain. These data show that TNF exerts metabolic effects on macrophage-rich tissues, and suggest that enhanced secretion of TNF may be one of the important factors in eliciting the metabolic changes in sepsis and endotoxicosis.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	149
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(87)91596-8
State	Published - Nov 30 1987

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1016/0006-291X(87)91596-8

Cite this

@article{77b6f6d4ea68403fac953e35b07910b7,

title = "Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues",

abstract = "Glucose utilization of different tissues was investigated in vivo by the 2-deoxyglucose tracer technique. After infusion of a non-lethal dose of recombinant human TNF-α (150 μg/kg) to rats, glucose utilization was increased by 80-100% in spleen, liver, kidney, by 60% in skin and by 30-40% in lung and ileum. The largest increase (150%) was observed in the diaphragm. There was no significant change in glucose utilization by skeletal muscles, testis and brain. These data show that TNF exerts metabolic effects on macrophage-rich tissues, and suggest that enhanced secretion of TNF may be one of the important factors in eliciting the metabolic changes in sepsis and endotoxicosis.",

author = "K{\'a}roly M{\'e}sz{\'a}ros and Lang, {Charles H.} and Bagby, {Gregory J.} and Spitzer, {John J.}",

note = "Funding Information: ACKNOWLEDGMENTS: The excellent technical assistance of June Bechtel is gratefully acknowledged. This work was supported National Institutes of Health Grant GM-32654.",

year = "1987",

month = nov,

day = "30",

doi = "10.1016/0006-291X(87)91596-8",

language = "English (US)",

volume = "149",

pages = "1--6",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues

AU - Mészáros, Károly

AU - Lang, Charles H.

AU - Bagby, Gregory J.

AU - Spitzer, John J.

N1 - Funding Information: ACKNOWLEDGMENTS: The excellent technical assistance of June Bechtel is gratefully acknowledged. This work was supported National Institutes of Health Grant GM-32654.

PY - 1987/11/30

Y1 - 1987/11/30

N2 - Glucose utilization of different tissues was investigated in vivo by the 2-deoxyglucose tracer technique. After infusion of a non-lethal dose of recombinant human TNF-α (150 μg/kg) to rats, glucose utilization was increased by 80-100% in spleen, liver, kidney, by 60% in skin and by 30-40% in lung and ileum. The largest increase (150%) was observed in the diaphragm. There was no significant change in glucose utilization by skeletal muscles, testis and brain. These data show that TNF exerts metabolic effects on macrophage-rich tissues, and suggest that enhanced secretion of TNF may be one of the important factors in eliciting the metabolic changes in sepsis and endotoxicosis.

AB - Glucose utilization of different tissues was investigated in vivo by the 2-deoxyglucose tracer technique. After infusion of a non-lethal dose of recombinant human TNF-α (150 μg/kg) to rats, glucose utilization was increased by 80-100% in spleen, liver, kidney, by 60% in skin and by 30-40% in lung and ileum. The largest increase (150%) was observed in the diaphragm. There was no significant change in glucose utilization by skeletal muscles, testis and brain. These data show that TNF exerts metabolic effects on macrophage-rich tissues, and suggest that enhanced secretion of TNF may be one of the important factors in eliciting the metabolic changes in sepsis and endotoxicosis.

UR - http://www.scopus.com/inward/record.url?scp=0023276322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023276322&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(87)91596-8

DO - 10.1016/0006-291X(87)91596-8

M3 - Article

C2 - 3689407

AN - SCOPUS:0023276322

VL - 149

SP - 1

EP - 6

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 1

ER -

Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this