Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues

Károly Mészáros; Charles H. Lang; Gregory J. Bagby; John J. Spitzer

doi:10.1016/0006-291X(87)91596-8

Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues

Károly Mészáros, Charles H. Lang, Gregory J. Bagby, John J. Spitzer

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Abstract

Glucose utilization of different tissues was investigated in vivo by the 2-deoxyglucose tracer technique. After infusion of a non-lethal dose of recombinant human TNF-α (150 μg/kg) to rats, glucose utilization was increased by 80-100% in spleen, liver, kidney, by 60% in skin and by 30-40% in lung and ileum. The largest increase (150%) was observed in the diaphragm. There was no significant change in glucose utilization by skeletal muscles, testis and brain. These data show that TNF exerts metabolic effects on macrophage-rich tissues, and suggest that enhanced secretion of TNF may be one of the important factors in eliciting the metabolic changes in sepsis and endotoxicosis.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	149
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(87)91596-8
State	Published - Nov 30 1987

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues",

abstract = "Glucose utilization of different tissues was investigated in vivo by the 2-deoxyglucose tracer technique. After infusion of a non-lethal dose of recombinant human TNF-α (150 μg/kg) to rats, glucose utilization was increased by 80-100% in spleen, liver, kidney, by 60% in skin and by 30-40% in lung and ileum. The largest increase (150%) was observed in the diaphragm. There was no significant change in glucose utilization by skeletal muscles, testis and brain. These data show that TNF exerts metabolic effects on macrophage-rich tissues, and suggest that enhanced secretion of TNF may be one of the important factors in eliciting the metabolic changes in sepsis and endotoxicosis.",

author = "K{\'a}roly M{\'e}sz{\'a}ros and Lang, {Charles H.} and Bagby, {Gregory J.} and Spitzer, {John J.}",

note = "Funding Information: ACKNOWLEDGMENTS: The excellent technical assistance of June Bechtel is gratefully acknowledged. This work was supported National Institutes of Health Grant GM-32654.",

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T1 - Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues

AU - Mészáros, Károly

AU - Lang, Charles H.

AU - Bagby, Gregory J.

AU - Spitzer, John J.

N1 - Funding Information: ACKNOWLEDGMENTS: The excellent technical assistance of June Bechtel is gratefully acknowledged. This work was supported National Institutes of Health Grant GM-32654.

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Y1 - 1987/11/30

N2 - Glucose utilization of different tissues was investigated in vivo by the 2-deoxyglucose tracer technique. After infusion of a non-lethal dose of recombinant human TNF-α (150 μg/kg) to rats, glucose utilization was increased by 80-100% in spleen, liver, kidney, by 60% in skin and by 30-40% in lung and ileum. The largest increase (150%) was observed in the diaphragm. There was no significant change in glucose utilization by skeletal muscles, testis and brain. These data show that TNF exerts metabolic effects on macrophage-rich tissues, and suggest that enhanced secretion of TNF may be one of the important factors in eliciting the metabolic changes in sepsis and endotoxicosis.

AB - Glucose utilization of different tissues was investigated in vivo by the 2-deoxyglucose tracer technique. After infusion of a non-lethal dose of recombinant human TNF-α (150 μg/kg) to rats, glucose utilization was increased by 80-100% in spleen, liver, kidney, by 60% in skin and by 30-40% in lung and ileum. The largest increase (150%) was observed in the diaphragm. There was no significant change in glucose utilization by skeletal muscles, testis and brain. These data show that TNF exerts metabolic effects on macrophage-rich tissues, and suggest that enhanced secretion of TNF may be one of the important factors in eliciting the metabolic changes in sepsis and endotoxicosis.

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Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues

Abstract

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