Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues

Károly Mészáros, Charles H. Lang, Gregory J. Bagby, John J. Spitzer

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Glucose utilization of different tissues was investigated in vivo by the 2-deoxyglucose tracer technique. After infusion of a non-lethal dose of recombinant human TNF-α (150 μg/kg) to rats, glucose utilization was increased by 80-100% in spleen, liver, kidney, by 60% in skin and by 30-40% in lung and ileum. The largest increase (150%) was observed in the diaphragm. There was no significant change in glucose utilization by skeletal muscles, testis and brain. These data show that TNF exerts metabolic effects on macrophage-rich tissues, and suggest that enhanced secretion of TNF may be one of the important factors in eliciting the metabolic changes in sepsis and endotoxicosis.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume149
Issue number1
DOIs
StatePublished - Nov 30 1987

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues'. Together they form a unique fingerprint.

Cite this