Tumorigenicity and metabolism of 1-nitropyrene in A/J mice

Karam El-bayoumy, Stephen S. Hecht, Terri Sackl, Gary D. Stoner

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Four groups of 28-32 male and female A/J mice were given i.p. injections of either trioctanoin or 1-nitropyrene In trioctanoin such that the total doses of 1-nitropyrene were 0.71 mmol/kg, 2.14 mmol/kg, or 6.44 mmol/kg. The mean number of lung tumors/mouse was 1.3± 1.0 in the group treated with 6.44 mmol/kg of 1-nitropyrene compared with 0.3± 0.6 in the trioctanoin group (p <0.001). Combined tumor incidence was not significant compared with controls in the two lower dose groups. Cultured explants of A/J mouse lung, and 9000 g supernatant of A/J mouse lung and liver, metabolized [14C]1-nitropyrene to 4,5-dihydro-4,5-dihydroxy-1-nitropyrene and 1-nitrohydroxypyrenes. Substantial amounts of unknown polar metabolites were also produced by cultured lung. Nitro-reduction to 1-aminopyrene was minimal in mouse lung and liver, even under oxygen deficient conditions.

Original languageEnglish (US)
Pages (from-to)1449-1452
Number of pages4
JournalCarcinogenesis
Volume5
Issue number11
DOIs
StatePublished - Nov 1 1984

All Science Journal Classification (ASJC) codes

  • Cancer Research

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