Tumors of Smooth-Muscle Origin in HIV-Infected Children

Ellen Gould Chadwick, Edward J. Connor, I. Celine Guerra Hanson, Vijay V. Joshi, Hussam Abu Farsakh, Ram Yogev, George McSherry, Kenneth Mcclain, Sharon B. Murphy

Research output: Contribution to journalArticle

165 Citations (Scopus)

Abstract

We report the occurrence of multiple leiomyomata and leiomyosarcomata in three children with the acquired immunodeficiency syndrome. The children were infected with human immunodeficiency virus as infants (one perinatally and two through transfusions) and each was profoundly immunosuppressed (absolute CD4 cell count, <75/mm3). They experienced multiple infections prior to the diagnosis of neoplasms at ages 4, 5, and 8 years, respectively. The tumors in each case were mainly involving the lungs and gastrointestinal tract. The smooth-muscle origin of the tumors was proved by light and electron microscopy and immunohistochemical staining for muscle-specific actin and desmin. Leiomyomata and leiomyosarcomata are rare tumors in childhood, suggesting a nonrandom association of tumors of smooth-muscle origin and the acquired immunodeficiency syndrome. We postulate that human immunodeficiency virus infection may play a direct or indirect role in tumor formation.

Original languageEnglish (US)
Pages (from-to)3182-3184
Number of pages3
JournalJAMA: The Journal of the American Medical Association
Volume263
Issue number23
DOIs
StatePublished - Jun 20 1990

Fingerprint

Smooth Muscle Tumor
HIV
Leiomyosarcoma
Leiomyoma
Neoplasms
Acquired Immunodeficiency Syndrome
Desmin
Virus Diseases
CD4 Lymphocyte Count
Gastrointestinal Tract
Actins
Electron Microscopy
Staining and Labeling
Light
Muscles
Lung
Infection

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chadwick, E. G., Connor, E. J., Hanson, I. C. G., Joshi, V. V., Abu Farsakh, H., Yogev, R., ... Murphy, S. B. (1990). Tumors of Smooth-Muscle Origin in HIV-Infected Children. JAMA: The Journal of the American Medical Association, 263(23), 3182-3184. https://doi.org/10.1001/jama.1990.03440230078037
Chadwick, Ellen Gould ; Connor, Edward J. ; Hanson, I. Celine Guerra ; Joshi, Vijay V. ; Abu Farsakh, Hussam ; Yogev, Ram ; McSherry, George ; Mcclain, Kenneth ; Murphy, Sharon B. / Tumors of Smooth-Muscle Origin in HIV-Infected Children. In: JAMA: The Journal of the American Medical Association. 1990 ; Vol. 263, No. 23. pp. 3182-3184.
@article{eadd110bc9e145ca81622366dc4b8874,
title = "Tumors of Smooth-Muscle Origin in HIV-Infected Children",
abstract = "We report the occurrence of multiple leiomyomata and leiomyosarcomata in three children with the acquired immunodeficiency syndrome. The children were infected with human immunodeficiency virus as infants (one perinatally and two through transfusions) and each was profoundly immunosuppressed (absolute CD4 cell count, <75/mm3). They experienced multiple infections prior to the diagnosis of neoplasms at ages 4, 5, and 8 years, respectively. The tumors in each case were mainly involving the lungs and gastrointestinal tract. The smooth-muscle origin of the tumors was proved by light and electron microscopy and immunohistochemical staining for muscle-specific actin and desmin. Leiomyomata and leiomyosarcomata are rare tumors in childhood, suggesting a nonrandom association of tumors of smooth-muscle origin and the acquired immunodeficiency syndrome. We postulate that human immunodeficiency virus infection may play a direct or indirect role in tumor formation.",
author = "Chadwick, {Ellen Gould} and Connor, {Edward J.} and Hanson, {I. Celine Guerra} and Joshi, {Vijay V.} and {Abu Farsakh}, Hussam and Ram Yogev and George McSherry and Kenneth Mcclain and Murphy, {Sharon B.}",
year = "1990",
month = "6",
day = "20",
doi = "10.1001/jama.1990.03440230078037",
language = "English (US)",
volume = "263",
pages = "3182--3184",
journal = "JAMA - Journal of the American Medical Association",
issn = "0002-9955",
publisher = "American Medical Association",
number = "23",

}

Chadwick, EG, Connor, EJ, Hanson, ICG, Joshi, VV, Abu Farsakh, H, Yogev, R, McSherry, G, Mcclain, K & Murphy, SB 1990, 'Tumors of Smooth-Muscle Origin in HIV-Infected Children', JAMA: The Journal of the American Medical Association, vol. 263, no. 23, pp. 3182-3184. https://doi.org/10.1001/jama.1990.03440230078037

Tumors of Smooth-Muscle Origin in HIV-Infected Children. / Chadwick, Ellen Gould; Connor, Edward J.; Hanson, I. Celine Guerra; Joshi, Vijay V.; Abu Farsakh, Hussam; Yogev, Ram; McSherry, George; Mcclain, Kenneth; Murphy, Sharon B.

In: JAMA: The Journal of the American Medical Association, Vol. 263, No. 23, 20.06.1990, p. 3182-3184.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Tumors of Smooth-Muscle Origin in HIV-Infected Children

AU - Chadwick, Ellen Gould

AU - Connor, Edward J.

AU - Hanson, I. Celine Guerra

AU - Joshi, Vijay V.

AU - Abu Farsakh, Hussam

AU - Yogev, Ram

AU - McSherry, George

AU - Mcclain, Kenneth

AU - Murphy, Sharon B.

PY - 1990/6/20

Y1 - 1990/6/20

N2 - We report the occurrence of multiple leiomyomata and leiomyosarcomata in three children with the acquired immunodeficiency syndrome. The children were infected with human immunodeficiency virus as infants (one perinatally and two through transfusions) and each was profoundly immunosuppressed (absolute CD4 cell count, <75/mm3). They experienced multiple infections prior to the diagnosis of neoplasms at ages 4, 5, and 8 years, respectively. The tumors in each case were mainly involving the lungs and gastrointestinal tract. The smooth-muscle origin of the tumors was proved by light and electron microscopy and immunohistochemical staining for muscle-specific actin and desmin. Leiomyomata and leiomyosarcomata are rare tumors in childhood, suggesting a nonrandom association of tumors of smooth-muscle origin and the acquired immunodeficiency syndrome. We postulate that human immunodeficiency virus infection may play a direct or indirect role in tumor formation.

AB - We report the occurrence of multiple leiomyomata and leiomyosarcomata in three children with the acquired immunodeficiency syndrome. The children were infected with human immunodeficiency virus as infants (one perinatally and two through transfusions) and each was profoundly immunosuppressed (absolute CD4 cell count, <75/mm3). They experienced multiple infections prior to the diagnosis of neoplasms at ages 4, 5, and 8 years, respectively. The tumors in each case were mainly involving the lungs and gastrointestinal tract. The smooth-muscle origin of the tumors was proved by light and electron microscopy and immunohistochemical staining for muscle-specific actin and desmin. Leiomyomata and leiomyosarcomata are rare tumors in childhood, suggesting a nonrandom association of tumors of smooth-muscle origin and the acquired immunodeficiency syndrome. We postulate that human immunodeficiency virus infection may play a direct or indirect role in tumor formation.

UR - http://www.scopus.com/inward/record.url?scp=0025332698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025332698&partnerID=8YFLogxK

U2 - 10.1001/jama.1990.03440230078037

DO - 10.1001/jama.1990.03440230078037

M3 - Article

C2 - 2348529

AN - SCOPUS:0025332698

VL - 263

SP - 3182

EP - 3184

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

SN - 0002-9955

IS - 23

ER -

Chadwick EG, Connor EJ, Hanson ICG, Joshi VV, Abu Farsakh H, Yogev R et al. Tumors of Smooth-Muscle Origin in HIV-Infected Children. JAMA: The Journal of the American Medical Association. 1990 Jun 20;263(23):3182-3184. https://doi.org/10.1001/jama.1990.03440230078037