Tuning antimicrobial properties of biomimetic nanopatterned surfaces

Martyna Michalska, Francesca Gambacorta, Ralu Divan, Igor S. Aranson, Andrey Sokolov, Philippe Noirot, Philip D. Laible

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Nature has amassed an impressive array of structures that afford protection from microbial colonization/infection when displayed on the exterior surfaces of organisms. Here, controlled variation of the features of mimetics derived from etched silicon allows for tuning of their antimicrobial efficacy. Materials with nanopillars up to 7 μm in length are extremely effective against a wide range of microbial species and exceed the performance of natural surfaces; in contrast, materials with shorter/blunter nanopillars (<2 μm) selectively killed specific species. Using a combination of microscopies, the mechanisms by which bacteria are killed are demonstrated, emphasizing the dependence upon pillar density and tip geometry. Additionally, real-time imaging reveals how cells are immobilized and killed rapidly. Generic or selective protection from microbial colonization could be conferred to surfaces [for, e.g., internal medicine, implants (joint, dental, and cosmetic), food preparation, and the agricultural industry] patterned with these materials as coatings.

Original languageEnglish (US)
Pages (from-to)6639-6650
Number of pages12
JournalNanoscale
Volume10
Issue number14
DOIs
StatePublished - Apr 14 2018

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Biomimetics
Tuning
Cosmetics
Silicon
Contrast Media
Bacteria
Microscopic examination
Imaging techniques
Coatings
Geometry
Industry

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Michalska, M., Gambacorta, F., Divan, R., Aranson, I. S., Sokolov, A., Noirot, P., & Laible, P. D. (2018). Tuning antimicrobial properties of biomimetic nanopatterned surfaces. Nanoscale, 10(14), 6639-6650. https://doi.org/10.1039/c8nr00439k
Michalska, Martyna ; Gambacorta, Francesca ; Divan, Ralu ; Aranson, Igor S. ; Sokolov, Andrey ; Noirot, Philippe ; Laible, Philip D. / Tuning antimicrobial properties of biomimetic nanopatterned surfaces. In: Nanoscale. 2018 ; Vol. 10, No. 14. pp. 6639-6650.
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Michalska, M, Gambacorta, F, Divan, R, Aranson, IS, Sokolov, A, Noirot, P & Laible, PD 2018, 'Tuning antimicrobial properties of biomimetic nanopatterned surfaces', Nanoscale, vol. 10, no. 14, pp. 6639-6650. https://doi.org/10.1039/c8nr00439k

Tuning antimicrobial properties of biomimetic nanopatterned surfaces. / Michalska, Martyna; Gambacorta, Francesca; Divan, Ralu; Aranson, Igor S.; Sokolov, Andrey; Noirot, Philippe; Laible, Philip D.

In: Nanoscale, Vol. 10, No. 14, 14.04.2018, p. 6639-6650.

Research output: Contribution to journalArticle

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Michalska M, Gambacorta F, Divan R, Aranson IS, Sokolov A, Noirot P et al. Tuning antimicrobial properties of biomimetic nanopatterned surfaces. Nanoscale. 2018 Apr 14;10(14):6639-6650. https://doi.org/10.1039/c8nr00439k