TY - JOUR
T1 - Tuning antimicrobial properties of biomimetic nanopatterned surfaces
AU - Michalska, Martyna
AU - Gambacorta, Francesca
AU - Divan, Ralu
AU - Aranson, Igor S.
AU - Sokolov, Andrey
AU - Noirot, Philippe
AU - Laible, Philip D.
N1 - Funding Information:
The authors thank Deborah Hanson, Marie-Françoise Gros, Gasper Kokot and Claire Kohout for discussions. This material is based upon work supported by Laboratory Directed Research and Development (LDRD) funding from Argonne National Laboratory, provided by the Director, Office of Science, of the U.S. Department of Energy under Contract No. DE-AC02-06CH11357. Use of the Center for Nanoscale Materials, an Office of Science user facility, was supported by the U. S. Department of Energy, Office of Science, Basic Energy Sciences, under the same contract.
Publisher Copyright:
© 2018 The Royal Society of Chemistry.
PY - 2018/4/14
Y1 - 2018/4/14
N2 - Nature has amassed an impressive array of structures that afford protection from microbial colonization/infection when displayed on the exterior surfaces of organisms. Here, controlled variation of the features of mimetics derived from etched silicon allows for tuning of their antimicrobial efficacy. Materials with nanopillars up to 7 μm in length are extremely effective against a wide range of microbial species and exceed the performance of natural surfaces; in contrast, materials with shorter/blunter nanopillars (<2 μm) selectively killed specific species. Using a combination of microscopies, the mechanisms by which bacteria are killed are demonstrated, emphasizing the dependence upon pillar density and tip geometry. Additionally, real-time imaging reveals how cells are immobilized and killed rapidly. Generic or selective protection from microbial colonization could be conferred to surfaces [for, e.g., internal medicine, implants (joint, dental, and cosmetic), food preparation, and the agricultural industry] patterned with these materials as coatings.
AB - Nature has amassed an impressive array of structures that afford protection from microbial colonization/infection when displayed on the exterior surfaces of organisms. Here, controlled variation of the features of mimetics derived from etched silicon allows for tuning of their antimicrobial efficacy. Materials with nanopillars up to 7 μm in length are extremely effective against a wide range of microbial species and exceed the performance of natural surfaces; in contrast, materials with shorter/blunter nanopillars (<2 μm) selectively killed specific species. Using a combination of microscopies, the mechanisms by which bacteria are killed are demonstrated, emphasizing the dependence upon pillar density and tip geometry. Additionally, real-time imaging reveals how cells are immobilized and killed rapidly. Generic or selective protection from microbial colonization could be conferred to surfaces [for, e.g., internal medicine, implants (joint, dental, and cosmetic), food preparation, and the agricultural industry] patterned with these materials as coatings.
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U2 - 10.1039/c8nr00439k
DO - 10.1039/c8nr00439k
M3 - Article
C2 - 29582025
AN - SCOPUS:85045151108
VL - 10
SP - 6639
EP - 6650
JO - Nanoscale
JF - Nanoscale
SN - 2040-3364
IS - 14
ER -