Turning induced by unilateral injection of antimicrotubular agents into the substantia nigra

Mark R. Brann, Molly Finnerty, John Ellis, Robert H. Lenox, Yigal H. Ehrlich

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Abstract1.Male Sprague-Dawley rats were given unilateral injections of colchicine, vinblastine, or saline into the substantia nigra pars compacta.2.The injection of vinblastine or colchicine produced a motor imbalance which was manifested as a turning away (contralateral rotation) from the injected side. This effect decreased over a period of days.3.These data suggest that disruption of microtubule-dependent systems within the nigra may result in a functional stimulation of the nigrostriatal pathway.

Original languageEnglish (US)
Pages (from-to)347-350
Number of pages4
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume6
Issue number4-6
DOIs
StatePublished - 1982

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Vinblastine
Colchicine
Substantia Nigra
Injections
Microtubules
Sprague Dawley Rats

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

Cite this

Brann, Mark R. ; Finnerty, Molly ; Ellis, John ; Lenox, Robert H. ; Ehrlich, Yigal H. / Turning induced by unilateral injection of antimicrotubular agents into the substantia nigra. In: Progress in Neuropsychopharmacology and Biological Psychiatry. 1982 ; Vol. 6, No. 4-6. pp. 347-350.
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Turning induced by unilateral injection of antimicrotubular agents into the substantia nigra. / Brann, Mark R.; Finnerty, Molly; Ellis, John; Lenox, Robert H.; Ehrlich, Yigal H.

In: Progress in Neuropsychopharmacology and Biological Psychiatry, Vol. 6, No. 4-6, 1982, p. 347-350.

Research output: Contribution to journalArticle

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