Turning induced by unilateral injection of antimicrotubular agents into the substantia nigra

Mark R. Brann, Molly Finnerty, John Ellis, Robert H. Lenox, Yigal H. Ehrlich

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Abstract1.Male Sprague-Dawley rats were given unilateral injections of colchicine, vinblastine, or saline into the substantia nigra pars compacta.2.The injection of vinblastine or colchicine produced a motor imbalance which was manifested as a turning away (contralateral rotation) from the injected side. This effect decreased over a period of days.3.These data suggest that disruption of microtubule-dependent systems within the nigra may result in a functional stimulation of the nigrostriatal pathway.

Original languageEnglish (US)
Pages (from-to)347-350
Number of pages4
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume6
Issue number4-6
DOIs
StatePublished - 1982

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

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