Two compartment microdialysis microdevice for continuous protein extraction from whole blood

Kiana Aran, Alex Fok, Jeffery Zahn, Akif Ündar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This work presents the design of a continuous microdialysis based blood protein extraction system to be used for clinical monitoring of inflammatory responses in patients undergoing cardiac surgery. The microdialysis system consists of a two compartment mass exchanger with two sets of polydimethylsiloxane (PDMS) microchannels separated by a porous polycarbonate membrane. Whole blood flows through channels on one side of the membrane (reservoir channels), while an isotonic perfusion fluid flows on the other side (perfusion channels). The membrane has a pore size of 400 nm, allowing free diffusion of small molecules and proteins across the membrane while excluding blood cells and platelets to obtain a clean, cell-free perfusate for analysis.

Original languageEnglish (US)
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1103-1105
Number of pages3
ISBN (Print)9780979806421
StatePublished - Jan 1 2009
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: Nov 1 2009Nov 5 2009

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of
CityJeju
Period11/1/0911/5/09

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Aran, K., Fok, A., Zahn, J., & Ündar, A. (2009). Two compartment microdialysis microdevice for continuous protein extraction from whole blood. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1103-1105). (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.