Two-step modification process to improve mechanical properties and bioactivity of hydroxyfluorapatite scaffolds

Sorour Sadeghzade, Rahmatollah Emadi, Batol Soleimani, Fariborz Tavangarian

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Porous ceramic scaffolds are synthetic implants, which support cell migration and establish sufficient extracellular matrix (ECM) and cell-cell interactions to heal bone defects. Hydroxyapatite (HA) scaffolds is one of the most suitable synthetic scaffolds for hard tissue replacement due to their bioactivity, biocompatibility and biomimetic features. However, the major disadvantages of HA is poor mechanical properties as well as low degradability rate and apatite formation ability. In this study, we developed a new method to improve the bioactivity, biodegradability and mechanical properties of natural hydroxyfluorapatite (HFA) by applying two-step coating process including ceramic and polymer coats. The structure, morphology and bioactivity potential of the modified and unmodified nanocomposite scaffolds were evaluated using transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and energy dispersive spectroscopy (EDS). The scaffold with optimized mechanical properties was HFA-30 wt%HT (HT stands for hardystonite) with a total porosity and pore size of 89 ± 1 and 900–1000 µm, respectively. The compressive modulus and strength of HFA (porosity ~ 93 ± 1) were improved from 108.81 ± 11.12–251.45 ± 12.2 MPa and 0.46 ± 0.1–1.7 ± 0.3 MPa in HFA-30 wt%HT sample, respectively. After applying poly(ε-caprolactone fumarate) (PCLF) polymer coating, the compressive strength and modules increased to 2.8 ± 0.15 and 426.1 ± 15.14 MPa, respectively. The apatite formation ability of scaffolds was investigated using simulated body fluid (SBF). The results showed that applying the hardystonite coating improve the apatite formation ability; however, the release of ions increased the pH. Whereas, modified scaffolds with PCLF could control the release of ions and improve the apatite formation ability as well.

Original languageEnglish (US)
Pages (from-to)19756-19763
Number of pages8
JournalCeramics International
Volume44
Issue number16
DOIs
StatePublished - Nov 1 2018

Fingerprint

Apatites
Apatite
Scaffolds (biology)
Bioactivity
Scaffolds
Mechanical properties
Durapatite
Hydroxyapatite
Coatings
Polymers
Porosity
Ions
Biodegradability
Body fluids
Biomimetics
Biocompatibility
Compressive strength
Pore size
Fourier transform infrared spectroscopy
Energy dispersive spectroscopy

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Process Chemistry and Technology
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this

Sadeghzade, Sorour ; Emadi, Rahmatollah ; Soleimani, Batol ; Tavangarian, Fariborz. / Two-step modification process to improve mechanical properties and bioactivity of hydroxyfluorapatite scaffolds. In: Ceramics International. 2018 ; Vol. 44, No. 16. pp. 19756-19763.
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abstract = "Porous ceramic scaffolds are synthetic implants, which support cell migration and establish sufficient extracellular matrix (ECM) and cell-cell interactions to heal bone defects. Hydroxyapatite (HA) scaffolds is one of the most suitable synthetic scaffolds for hard tissue replacement due to their bioactivity, biocompatibility and biomimetic features. However, the major disadvantages of HA is poor mechanical properties as well as low degradability rate and apatite formation ability. In this study, we developed a new method to improve the bioactivity, biodegradability and mechanical properties of natural hydroxyfluorapatite (HFA) by applying two-step coating process including ceramic and polymer coats. The structure, morphology and bioactivity potential of the modified and unmodified nanocomposite scaffolds were evaluated using transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and energy dispersive spectroscopy (EDS). The scaffold with optimized mechanical properties was HFA-30 wt{\%}HT (HT stands for hardystonite) with a total porosity and pore size of 89 ± 1 and 900–1000 µm, respectively. The compressive modulus and strength of HFA (porosity ~ 93 ± 1) were improved from 108.81 ± 11.12–251.45 ± 12.2 MPa and 0.46 ± 0.1–1.7 ± 0.3 MPa in HFA-30 wt{\%}HT sample, respectively. After applying poly(ε-caprolactone fumarate) (PCLF) polymer coating, the compressive strength and modules increased to 2.8 ± 0.15 and 426.1 ± 15.14 MPa, respectively. The apatite formation ability of scaffolds was investigated using simulated body fluid (SBF). The results showed that applying the hardystonite coating improve the apatite formation ability; however, the release of ions increased the pH. Whereas, modified scaffolds with PCLF could control the release of ions and improve the apatite formation ability as well.",
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Two-step modification process to improve mechanical properties and bioactivity of hydroxyfluorapatite scaffolds. / Sadeghzade, Sorour; Emadi, Rahmatollah; Soleimani, Batol; Tavangarian, Fariborz.

In: Ceramics International, Vol. 44, No. 16, 01.11.2018, p. 19756-19763.

Research output: Contribution to journalArticle

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AU - Emadi, Rahmatollah

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