Two types of poor immunological responder showing distinct responses to long-term HAART

Yaxian Kong, Yunfei Tian, Yu Hao, Xuejing Chong, Jiang Xiao, Di Yang, Chuan Song, Junyan Han, Guorui Dai, Fujie Zhang, Hong Zheng, Hongxin Zhao, Hui Zeng

Research output: Contribution to journalArticle

Abstract

Objectives: Most previous studies on poor immunological responders (PIRs) have been performed on one cohort at one time-point following highly active antiretroviral therapy (HAART). The aim of this study was to investigate whether there are different subtypes of PIR and whether a certain population might achieve better immune reconstitution following longer HAART. Methods: This study was designed as an ambispective cohort study, including a 4–5-year retrospective study and a 2-year prospective follow-up investigation. Thymic output, activated T cell and regulatory T cell (Treg) subset frequencies, expression levels of interferon-stimulated genes, and plasma concentrations of neopterin were determined at 4–5 years and 6–7 years following HAART initiation. Results: PIRs were subdivided into two populations after 4–5 years of HAART, according to the kinetics of T cell recovery. Type II PIRs exhibited a significantly lower percentage of naïve CD4+ T cells and CD31+ naïve CD4+ T cells compared with type I PIRs. After an additional 2 years of HAART treatment, type I PIRs showed a better outcome than type II PIRs. Furthermore, it was found that 2 years of additional HAART could persistently improve thymic output. Conclusions: The two PIR subgroups are different in terms of immune characteristics and the response to prolonged HAART.

Original languageEnglish (US)
Pages (from-to)178-187
Number of pages10
JournalInternational Journal of Infectious Diseases
Volume86
DOIs
StatePublished - Sep 1 2019

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Highly Active Antiretroviral Therapy
T-Lymphocytes
Neopterin
T-Lymphocyte Subsets
Regulatory T-Lymphocytes
Interferons
Population
Cohort Studies
Retrospective Studies
Genes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Kong, Yaxian ; Tian, Yunfei ; Hao, Yu ; Chong, Xuejing ; Xiao, Jiang ; Yang, Di ; Song, Chuan ; Han, Junyan ; Dai, Guorui ; Zhang, Fujie ; Zheng, Hong ; Zhao, Hongxin ; Zeng, Hui. / Two types of poor immunological responder showing distinct responses to long-term HAART. In: International Journal of Infectious Diseases. 2019 ; Vol. 86. pp. 178-187.
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abstract = "Objectives: Most previous studies on poor immunological responders (PIRs) have been performed on one cohort at one time-point following highly active antiretroviral therapy (HAART). The aim of this study was to investigate whether there are different subtypes of PIR and whether a certain population might achieve better immune reconstitution following longer HAART. Methods: This study was designed as an ambispective cohort study, including a 4–5-year retrospective study and a 2-year prospective follow-up investigation. Thymic output, activated T cell and regulatory T cell (Treg) subset frequencies, expression levels of interferon-stimulated genes, and plasma concentrations of neopterin were determined at 4–5 years and 6–7 years following HAART initiation. Results: PIRs were subdivided into two populations after 4–5 years of HAART, according to the kinetics of T cell recovery. Type II PIRs exhibited a significantly lower percentage of na{\"i}ve CD4+ T cells and CD31+ na{\"i}ve CD4+ T cells compared with type I PIRs. After an additional 2 years of HAART treatment, type I PIRs showed a better outcome than type II PIRs. Furthermore, it was found that 2 years of additional HAART could persistently improve thymic output. Conclusions: The two PIR subgroups are different in terms of immune characteristics and the response to prolonged HAART.",
author = "Yaxian Kong and Yunfei Tian and Yu Hao and Xuejing Chong and Jiang Xiao and Di Yang and Chuan Song and Junyan Han and Guorui Dai and Fujie Zhang and Hong Zheng and Hongxin Zhao and Hui Zeng",
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Kong, Y, Tian, Y, Hao, Y, Chong, X, Xiao, J, Yang, D, Song, C, Han, J, Dai, G, Zhang, F, Zheng, H, Zhao, H & Zeng, H 2019, 'Two types of poor immunological responder showing distinct responses to long-term HAART', International Journal of Infectious Diseases, vol. 86, pp. 178-187. https://doi.org/10.1016/j.ijid.2019.07.037

Two types of poor immunological responder showing distinct responses to long-term HAART. / Kong, Yaxian; Tian, Yunfei; Hao, Yu; Chong, Xuejing; Xiao, Jiang; Yang, Di; Song, Chuan; Han, Junyan; Dai, Guorui; Zhang, Fujie; Zheng, Hong; Zhao, Hongxin; Zeng, Hui.

In: International Journal of Infectious Diseases, Vol. 86, 01.09.2019, p. 178-187.

Research output: Contribution to journalArticle

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T1 - Two types of poor immunological responder showing distinct responses to long-term HAART

AU - Kong, Yaxian

AU - Tian, Yunfei

AU - Hao, Yu

AU - Chong, Xuejing

AU - Xiao, Jiang

AU - Yang, Di

AU - Song, Chuan

AU - Han, Junyan

AU - Dai, Guorui

AU - Zhang, Fujie

AU - Zheng, Hong

AU - Zhao, Hongxin

AU - Zeng, Hui

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Objectives: Most previous studies on poor immunological responders (PIRs) have been performed on one cohort at one time-point following highly active antiretroviral therapy (HAART). The aim of this study was to investigate whether there are different subtypes of PIR and whether a certain population might achieve better immune reconstitution following longer HAART. Methods: This study was designed as an ambispective cohort study, including a 4–5-year retrospective study and a 2-year prospective follow-up investigation. Thymic output, activated T cell and regulatory T cell (Treg) subset frequencies, expression levels of interferon-stimulated genes, and plasma concentrations of neopterin were determined at 4–5 years and 6–7 years following HAART initiation. Results: PIRs were subdivided into two populations after 4–5 years of HAART, according to the kinetics of T cell recovery. Type II PIRs exhibited a significantly lower percentage of naïve CD4+ T cells and CD31+ naïve CD4+ T cells compared with type I PIRs. After an additional 2 years of HAART treatment, type I PIRs showed a better outcome than type II PIRs. Furthermore, it was found that 2 years of additional HAART could persistently improve thymic output. Conclusions: The two PIR subgroups are different in terms of immune characteristics and the response to prolonged HAART.

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