Two types of poor immunological responder showing distinct responses to long-term HAART

Yaxian Kong, Yunfei Tian, Yu Hao, Xuejing Chong, Jiang Xiao, Di Yang, Chuan Song, Junyan Han, Guorui Dai, Fujie Zhang, Hong Zheng, Hongxin Zhao, Hui Zeng

Research output: Contribution to journalArticle

Abstract

Objectives: Most previous studies on poor immunological responders (PIRs) have been performed on one cohort at one time-point following highly active antiretroviral therapy (HAART). The aim of this study was to investigate whether there are different subtypes of PIR and whether a certain population might achieve better immune reconstitution following longer HAART. Methods: This study was designed as an ambispective cohort study, including a 4–5-year retrospective study and a 2-year prospective follow-up investigation. Thymic output, activated T cell and regulatory T cell (Treg) subset frequencies, expression levels of interferon-stimulated genes, and plasma concentrations of neopterin were determined at 4–5 years and 6–7 years following HAART initiation. Results: PIRs were subdivided into two populations after 4–5 years of HAART, according to the kinetics of T cell recovery. Type II PIRs exhibited a significantly lower percentage of naïve CD4+ T cells and CD31+ naïve CD4+ T cells compared with type I PIRs. After an additional 2 years of HAART treatment, type I PIRs showed a better outcome than type II PIRs. Furthermore, it was found that 2 years of additional HAART could persistently improve thymic output. Conclusions: The two PIR subgroups are different in terms of immune characteristics and the response to prolonged HAART.

Original languageEnglish (US)
Pages (from-to)178-187
Number of pages10
JournalInternational Journal of Infectious Diseases
Volume86
DOIs
StatePublished - Sep 2019

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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    Kong, Y., Tian, Y., Hao, Y., Chong, X., Xiao, J., Yang, D., Song, C., Han, J., Dai, G., Zhang, F., Zheng, H., Zhao, H., & Zeng, H. (2019). Two types of poor immunological responder showing distinct responses to long-term HAART. International Journal of Infectious Diseases, 86, 178-187. https://doi.org/10.1016/j.ijid.2019.07.037