□ We report on three previously undescribed unstable hemoglobin (Hb) variants: Hb Miami, Hb Hershey and Hb Abington. Hb Miami was associated with a β+-thalassemia (thal) mutation [IVS-I-110 (G→A)], whereas Hb Hershey was associated with a β0-thal mutation [IVS-I-1 (G→A)]. Hb Hershey also has decreased oxygen affinity. These three Hb variants illustrate the range of clinical severity that can be seen with unstable Hb variants, particularly when combined with a thalassemic mutation.
All Science Journal Classification (ASJC) codes
- Clinical Biochemistry
- Biochemistry, medical