Two weeks of exercise training intensity on appetite regulation in obese adults with prediabetes

Emily M. Heiston, Natalie Z.M. Eichner, Nicole Gilbertson, Julian M. Gaitán, Sibylle Kranz, Arthur Weltman, Steven K. Malin

Research output: Contribution to journalArticle

Abstract

No short-term exercise data exist testing whether training intensity modifies hormonal and perceived appetite in obese adults with prediabetes. Therefore, we compared the effects of short-term moderate-continuous (CONT) vs. high-intensity interval (INT) training on appetite regulation. Twenty-eight obese adults [age: 61.3 1.5 yr; body mass index (BMI): 33.2 1.1 kg/m2] with prediabetes were randomized to work-matched CONT (n 14) or INT (n 14) training for 2 wk. Plasma acylated ghrelin (AG), des-acylated ghrelin (dAG), active glucagon-like peptide-1 (GLP-1), and insulin were measured at 0, 30, and 60 min of a 75-g oral glucose tolerance test (OGTT) before and after training. Visual analog scales were administered at 0 and 120 min during the OGTT to examine perceived appetite. Three-day food logs were collected before and after testing to assess ad libitum diet. CONT and INT increased peak oxygen consumption (P 0.01) and decreased BMI (P 0.01). Although neither intervention altered fasting levels of AG (P 0.94), dAG (P 0.36), or insulin (P 0.67), CONT raised GLP-1 compared with INT (P 0.05). Exercise training did not affect postprandial suppression of AG (P 0.81) and dAG (P 0.67) or stimulation of GLP-1 (P 0.67) and insulin (P 0.32). Both interventions tended to decrease total energy and protein intake (P 0.09 and P 0.05, respectively), despite no change in fasting hunger (P 0.88) and reduced perceived fullness at 120 min during the OGTT (P 0.05). We conclude that 2 wk of exercise training intensity does not modulate appetite-regulatory hormones in obese adults with prediabetes. Although perceived fullness to the OGTT was reduced after exercise, CONT and INT decreased energy intake, suggesting that exercise does not elicit compensatory appetite behavior to gain weight.

Original languageEnglish (US)
Pages (from-to)746-754
Number of pages9
JournalJournal of applied physiology
Volume126
Issue number3
DOIs
StatePublished - Sep 29 2018

Fingerprint

Appetite Regulation
Prediabetic State
Ghrelin
Appetite
Exercise
Glucose Tolerance Test
Glucagon-Like Peptide 1
Insulin
Energy Intake
Fasting
Body Mass Index
Hunger
Visual Analog Scale
Oxygen Consumption
Weight Gain
Hormones
Diet
Food
Proteins

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Heiston, Emily M. ; Eichner, Natalie Z.M. ; Gilbertson, Nicole ; Gaitán, Julian M. ; Kranz, Sibylle ; Weltman, Arthur ; Malin, Steven K. / Two weeks of exercise training intensity on appetite regulation in obese adults with prediabetes. In: Journal of applied physiology. 2018 ; Vol. 126, No. 3. pp. 746-754.
@article{ccfbf802a24c45b3b2dc2fcf8e4a44f8,
title = "Two weeks of exercise training intensity on appetite regulation in obese adults with prediabetes",
abstract = "No short-term exercise data exist testing whether training intensity modifies hormonal and perceived appetite in obese adults with prediabetes. Therefore, we compared the effects of short-term moderate-continuous (CONT) vs. high-intensity interval (INT) training on appetite regulation. Twenty-eight obese adults [age: 61.3 1.5 yr; body mass index (BMI): 33.2 1.1 kg/m2] with prediabetes were randomized to work-matched CONT (n 14) or INT (n 14) training for 2 wk. Plasma acylated ghrelin (AG), des-acylated ghrelin (dAG), active glucagon-like peptide-1 (GLP-1), and insulin were measured at 0, 30, and 60 min of a 75-g oral glucose tolerance test (OGTT) before and after training. Visual analog scales were administered at 0 and 120 min during the OGTT to examine perceived appetite. Three-day food logs were collected before and after testing to assess ad libitum diet. CONT and INT increased peak oxygen consumption (P 0.01) and decreased BMI (P 0.01). Although neither intervention altered fasting levels of AG (P 0.94), dAG (P 0.36), or insulin (P 0.67), CONT raised GLP-1 compared with INT (P 0.05). Exercise training did not affect postprandial suppression of AG (P 0.81) and dAG (P 0.67) or stimulation of GLP-1 (P 0.67) and insulin (P 0.32). Both interventions tended to decrease total energy and protein intake (P 0.09 and P 0.05, respectively), despite no change in fasting hunger (P 0.88) and reduced perceived fullness at 120 min during the OGTT (P 0.05). We conclude that 2 wk of exercise training intensity does not modulate appetite-regulatory hormones in obese adults with prediabetes. Although perceived fullness to the OGTT was reduced after exercise, CONT and INT decreased energy intake, suggesting that exercise does not elicit compensatory appetite behavior to gain weight.",
author = "Heiston, {Emily M.} and Eichner, {Natalie Z.M.} and Nicole Gilbertson and Gait{\'a}n, {Julian M.} and Sibylle Kranz and Arthur Weltman and Malin, {Steven K.}",
year = "2018",
month = "9",
day = "29",
doi = "10.1152/japplphysiol.00655.2018",
language = "English (US)",
volume = "126",
pages = "746--754",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "3",

}

Two weeks of exercise training intensity on appetite regulation in obese adults with prediabetes. / Heiston, Emily M.; Eichner, Natalie Z.M.; Gilbertson, Nicole; Gaitán, Julian M.; Kranz, Sibylle; Weltman, Arthur; Malin, Steven K.

In: Journal of applied physiology, Vol. 126, No. 3, 29.09.2018, p. 746-754.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Two weeks of exercise training intensity on appetite regulation in obese adults with prediabetes

AU - Heiston, Emily M.

AU - Eichner, Natalie Z.M.

AU - Gilbertson, Nicole

AU - Gaitán, Julian M.

AU - Kranz, Sibylle

AU - Weltman, Arthur

AU - Malin, Steven K.

PY - 2018/9/29

Y1 - 2018/9/29

N2 - No short-term exercise data exist testing whether training intensity modifies hormonal and perceived appetite in obese adults with prediabetes. Therefore, we compared the effects of short-term moderate-continuous (CONT) vs. high-intensity interval (INT) training on appetite regulation. Twenty-eight obese adults [age: 61.3 1.5 yr; body mass index (BMI): 33.2 1.1 kg/m2] with prediabetes were randomized to work-matched CONT (n 14) or INT (n 14) training for 2 wk. Plasma acylated ghrelin (AG), des-acylated ghrelin (dAG), active glucagon-like peptide-1 (GLP-1), and insulin were measured at 0, 30, and 60 min of a 75-g oral glucose tolerance test (OGTT) before and after training. Visual analog scales were administered at 0 and 120 min during the OGTT to examine perceived appetite. Three-day food logs were collected before and after testing to assess ad libitum diet. CONT and INT increased peak oxygen consumption (P 0.01) and decreased BMI (P 0.01). Although neither intervention altered fasting levels of AG (P 0.94), dAG (P 0.36), or insulin (P 0.67), CONT raised GLP-1 compared with INT (P 0.05). Exercise training did not affect postprandial suppression of AG (P 0.81) and dAG (P 0.67) or stimulation of GLP-1 (P 0.67) and insulin (P 0.32). Both interventions tended to decrease total energy and protein intake (P 0.09 and P 0.05, respectively), despite no change in fasting hunger (P 0.88) and reduced perceived fullness at 120 min during the OGTT (P 0.05). We conclude that 2 wk of exercise training intensity does not modulate appetite-regulatory hormones in obese adults with prediabetes. Although perceived fullness to the OGTT was reduced after exercise, CONT and INT decreased energy intake, suggesting that exercise does not elicit compensatory appetite behavior to gain weight.

AB - No short-term exercise data exist testing whether training intensity modifies hormonal and perceived appetite in obese adults with prediabetes. Therefore, we compared the effects of short-term moderate-continuous (CONT) vs. high-intensity interval (INT) training on appetite regulation. Twenty-eight obese adults [age: 61.3 1.5 yr; body mass index (BMI): 33.2 1.1 kg/m2] with prediabetes were randomized to work-matched CONT (n 14) or INT (n 14) training for 2 wk. Plasma acylated ghrelin (AG), des-acylated ghrelin (dAG), active glucagon-like peptide-1 (GLP-1), and insulin were measured at 0, 30, and 60 min of a 75-g oral glucose tolerance test (OGTT) before and after training. Visual analog scales were administered at 0 and 120 min during the OGTT to examine perceived appetite. Three-day food logs were collected before and after testing to assess ad libitum diet. CONT and INT increased peak oxygen consumption (P 0.01) and decreased BMI (P 0.01). Although neither intervention altered fasting levels of AG (P 0.94), dAG (P 0.36), or insulin (P 0.67), CONT raised GLP-1 compared with INT (P 0.05). Exercise training did not affect postprandial suppression of AG (P 0.81) and dAG (P 0.67) or stimulation of GLP-1 (P 0.67) and insulin (P 0.32). Both interventions tended to decrease total energy and protein intake (P 0.09 and P 0.05, respectively), despite no change in fasting hunger (P 0.88) and reduced perceived fullness at 120 min during the OGTT (P 0.05). We conclude that 2 wk of exercise training intensity does not modulate appetite-regulatory hormones in obese adults with prediabetes. Although perceived fullness to the OGTT was reduced after exercise, CONT and INT decreased energy intake, suggesting that exercise does not elicit compensatory appetite behavior to gain weight.

UR - http://www.scopus.com/inward/record.url?scp=85063624898&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063624898&partnerID=8YFLogxK

U2 - 10.1152/japplphysiol.00655.2018

DO - 10.1152/japplphysiol.00655.2018

M3 - Article

C2 - 30629474

AN - SCOPUS:85063624898

VL - 126

SP - 746

EP - 754

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 3

ER -