Unapproved uses of approved drugs: The physician, the package insert, and the Food and Drug Administration: Subject review

Cheston Berlin, D. G. May, D. A. Notterman, R. M. Ward, D. N. Weismann, G. S. Wilson, J. T. Wilson

80 Scopus citations

Abstract

Physicians who prescribe a new drug that has not been approved for a specific indication or a specific age group frequently find themselves in a quandary. Physicians who prescribe 'old,' time-honored drugs usually do not consult the package insert or search for US Food and Drug Administration (FDA) approval. This statement was written to clarify the legal and informational status of the package insert and the role of the FDA in approving or not approving drugs for specific indications or specific age groups. The unapproved use of approved drugs, or so-called 'off-label' use, is extremely prevalent among physicians who care for children. It is important that such use of compounds be brought up to date with current FDA policies and to emphasize the responsibility of the prescribing physician in the use of these compounds.

Original languageEnglish (US)
Pages (from-to)143-145
Number of pages3
JournalPediatrics
Volume98
Issue number1
StatePublished - Jul 19 1996

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Berlin, Cheston ; May, D. G. ; Notterman, D. A. ; Ward, R. M. ; Weismann, D. N. ; Wilson, G. S. ; Wilson, J. T. / Unapproved uses of approved drugs : The physician, the package insert, and the Food and Drug Administration: Subject review. In: Pediatrics. 1996 ; Vol. 98, No. 1. pp. 143-145.