Unawareness of cognitive deficit (cognitive anosognosia) in probable AD and control subjects

Anna M. Barrett, Paul J. Eslinger, Noel H. Ballentine, Kenneth M. Heilman

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Objective: To develop a quantitative method of assessing cognitive anosognosia in six cognitive and two noncognitive domains. Methods: Control (n = 32) and probable Alzheimer disease (pAD) (n = 14) subjects self-estimated memory, attention, generative behavior, naming, visuospatial skill, limb praxis, mood, and uncorrected vision, both before and after these abilities were assessed. Based on this estimate and their performance the authors calculated an anosognosia ratio (AR) by dividing the difference between estimated and actual performance by an estimated and actual performance sum. With perfect awareness, AR = 0. Overestimating abilities would yield a positive AR (≤1); underestimation would yield a negative AR (≥-1). Results: Relative to controls, pAD subjects demonstrated anosognosia. Pre-testing (off-line), pAD subjects overestimated their visuospatial skill; post-testing (on-line), pAD subjects overestimated their memory. Control subjects also made self-rating errors, underestimating their attention pre-testing and overestimating limb praxis and vision post-testing. Conclusions: This anosognosia assessment method may allow more detailed examination of distorted self-awareness. These results suggest that screening for anosognosia in probable Alzheimer disease (pAD) should include self-estimates of visuospatial function, and that, in pAD, it may be useful to assess anosognosia for amnesia both before and after memory testing.

Original languageEnglish (US)
Pages (from-to)693-699
Number of pages7
JournalNeurology
Volume64
Issue number4
DOIs
StatePublished - Feb 22 2005

Fingerprint

Agnosia
Alzheimer Disease
Aptitude
Extremities
Amnesia

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

@article{1625043e943c41c58cf4480290ffeadb,
title = "Unawareness of cognitive deficit (cognitive anosognosia) in probable AD and control subjects",
abstract = "Objective: To develop a quantitative method of assessing cognitive anosognosia in six cognitive and two noncognitive domains. Methods: Control (n = 32) and probable Alzheimer disease (pAD) (n = 14) subjects self-estimated memory, attention, generative behavior, naming, visuospatial skill, limb praxis, mood, and uncorrected vision, both before and after these abilities were assessed. Based on this estimate and their performance the authors calculated an anosognosia ratio (AR) by dividing the difference between estimated and actual performance by an estimated and actual performance sum. With perfect awareness, AR = 0. Overestimating abilities would yield a positive AR (≤1); underestimation would yield a negative AR (≥-1). Results: Relative to controls, pAD subjects demonstrated anosognosia. Pre-testing (off-line), pAD subjects overestimated their visuospatial skill; post-testing (on-line), pAD subjects overestimated their memory. Control subjects also made self-rating errors, underestimating their attention pre-testing and overestimating limb praxis and vision post-testing. Conclusions: This anosognosia assessment method may allow more detailed examination of distorted self-awareness. These results suggest that screening for anosognosia in probable Alzheimer disease (pAD) should include self-estimates of visuospatial function, and that, in pAD, it may be useful to assess anosognosia for amnesia both before and after memory testing.",
author = "Barrett, {Anna M.} and Eslinger, {Paul J.} and Ballentine, {Noel H.} and Heilman, {Kenneth M.}",
year = "2005",
month = "2",
day = "22",
doi = "10.1212/01.WNL.0000151959.64379.1B",
language = "English (US)",
volume = "64",
pages = "693--699",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

Unawareness of cognitive deficit (cognitive anosognosia) in probable AD and control subjects. / Barrett, Anna M.; Eslinger, Paul J.; Ballentine, Noel H.; Heilman, Kenneth M.

In: Neurology, Vol. 64, No. 4, 22.02.2005, p. 693-699.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Unawareness of cognitive deficit (cognitive anosognosia) in probable AD and control subjects

AU - Barrett, Anna M.

AU - Eslinger, Paul J.

AU - Ballentine, Noel H.

AU - Heilman, Kenneth M.

PY - 2005/2/22

Y1 - 2005/2/22

N2 - Objective: To develop a quantitative method of assessing cognitive anosognosia in six cognitive and two noncognitive domains. Methods: Control (n = 32) and probable Alzheimer disease (pAD) (n = 14) subjects self-estimated memory, attention, generative behavior, naming, visuospatial skill, limb praxis, mood, and uncorrected vision, both before and after these abilities were assessed. Based on this estimate and their performance the authors calculated an anosognosia ratio (AR) by dividing the difference between estimated and actual performance by an estimated and actual performance sum. With perfect awareness, AR = 0. Overestimating abilities would yield a positive AR (≤1); underestimation would yield a negative AR (≥-1). Results: Relative to controls, pAD subjects demonstrated anosognosia. Pre-testing (off-line), pAD subjects overestimated their visuospatial skill; post-testing (on-line), pAD subjects overestimated their memory. Control subjects also made self-rating errors, underestimating their attention pre-testing and overestimating limb praxis and vision post-testing. Conclusions: This anosognosia assessment method may allow more detailed examination of distorted self-awareness. These results suggest that screening for anosognosia in probable Alzheimer disease (pAD) should include self-estimates of visuospatial function, and that, in pAD, it may be useful to assess anosognosia for amnesia both before and after memory testing.

AB - Objective: To develop a quantitative method of assessing cognitive anosognosia in six cognitive and two noncognitive domains. Methods: Control (n = 32) and probable Alzheimer disease (pAD) (n = 14) subjects self-estimated memory, attention, generative behavior, naming, visuospatial skill, limb praxis, mood, and uncorrected vision, both before and after these abilities were assessed. Based on this estimate and their performance the authors calculated an anosognosia ratio (AR) by dividing the difference between estimated and actual performance by an estimated and actual performance sum. With perfect awareness, AR = 0. Overestimating abilities would yield a positive AR (≤1); underestimation would yield a negative AR (≥-1). Results: Relative to controls, pAD subjects demonstrated anosognosia. Pre-testing (off-line), pAD subjects overestimated their visuospatial skill; post-testing (on-line), pAD subjects overestimated their memory. Control subjects also made self-rating errors, underestimating their attention pre-testing and overestimating limb praxis and vision post-testing. Conclusions: This anosognosia assessment method may allow more detailed examination of distorted self-awareness. These results suggest that screening for anosognosia in probable Alzheimer disease (pAD) should include self-estimates of visuospatial function, and that, in pAD, it may be useful to assess anosognosia for amnesia both before and after memory testing.

UR - http://www.scopus.com/inward/record.url?scp=13844320569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13844320569&partnerID=8YFLogxK

U2 - 10.1212/01.WNL.0000151959.64379.1B

DO - 10.1212/01.WNL.0000151959.64379.1B

M3 - Article

C2 - 15728294

AN - SCOPUS:13844320569

VL - 64

SP - 693

EP - 699

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 4

ER -