Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex

Shuzhen Hao, James W. Sharp, Catherine M. Ross-Inta, Brent J. McDaniel, Tracy G. Anthony, Ronald C. Wek, Douglas R. Cavener, Barbara Claire McGrath, John B. Rudell, Thomas J. Koehnle, Dorothy W. Gietzen

Research output: Contribution to journalArticle

232 Citations (Scopus)

Abstract

Recognizing a deficiency of indispensable amino acids (IAAs) for protein synthesis is vital for dietary selection in metazoans, including humans. Cells in the brain's anterior piriform cortex (APC) are sensitive to IAA deficiency, signaling diet rejection and foraging for complementary IAA sources, but the mechanism is unknown. Here we report that the mechanism for recognizing IAA-deficient foods follows the conserved general control (GC) system, wherein uncharged transfer RNA induces phosphorylation of eukaryotic initiation factor 2 (eIF2) via the GC nonderepressing 2 (GCN2) kinase. Thus, a basic mechanism of nutritional stress management functions in mammalian brain to guide food selection for survival.

Original languageEnglish (US)
Pages (from-to)1776-1778
Number of pages3
JournalScience
Volume307
Issue number5716
DOIs
StatePublished - Mar 18 2005

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Amino Acid-Specific Transfer RNA
Amino Acids
Eukaryotic Initiation Factor-2
Food Preferences
Brain
Transfer RNA
Phosphotransferases
Phosphorylation
Diet
Food
Survival
Piriform Cortex
Proteins

All Science Journal Classification (ASJC) codes

  • General

Cite this

Hao, S., Sharp, J. W., Ross-Inta, C. M., McDaniel, B. J., Anthony, T. G., Wek, R. C., ... Gietzen, D. W. (2005). Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science, 307(5716), 1776-1778. https://doi.org/10.1126/science.1104882
Hao, Shuzhen ; Sharp, James W. ; Ross-Inta, Catherine M. ; McDaniel, Brent J. ; Anthony, Tracy G. ; Wek, Ronald C. ; Cavener, Douglas R. ; McGrath, Barbara Claire ; Rudell, John B. ; Koehnle, Thomas J. ; Gietzen, Dorothy W. / Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. In: Science. 2005 ; Vol. 307, No. 5716. pp. 1776-1778.
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Hao, S, Sharp, JW, Ross-Inta, CM, McDaniel, BJ, Anthony, TG, Wek, RC, Cavener, DR, McGrath, BC, Rudell, JB, Koehnle, TJ & Gietzen, DW 2005, 'Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex', Science, vol. 307, no. 5716, pp. 1776-1778. https://doi.org/10.1126/science.1104882

Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. / Hao, Shuzhen; Sharp, James W.; Ross-Inta, Catherine M.; McDaniel, Brent J.; Anthony, Tracy G.; Wek, Ronald C.; Cavener, Douglas R.; McGrath, Barbara Claire; Rudell, John B.; Koehnle, Thomas J.; Gietzen, Dorothy W.

In: Science, Vol. 307, No. 5716, 18.03.2005, p. 1776-1778.

Research output: Contribution to journalArticle

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AU - Hao, Shuzhen

AU - Sharp, James W.

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AU - Anthony, Tracy G.

AU - Wek, Ronald C.

AU - Cavener, Douglas R.

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Hao S, Sharp JW, Ross-Inta CM, McDaniel BJ, Anthony TG, Wek RC et al. Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science. 2005 Mar 18;307(5716):1776-1778. https://doi.org/10.1126/science.1104882