Understanding biophysicochemical interactions at the nano-bio interface

Andre E. Nel, Lutz Mädler, Darrell Velegol, Tian Xia, Eric M.V. Hoek, Ponisseril Somasundaran, Fred Klaessig, Vince Castranova, Mike Thompson

Research output: Contribution to journalReview article

3863 Citations (Scopus)

Abstract

Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.

Original languageEnglish (US)
Pages (from-to)543-557
Number of pages15
JournalNature Materials
Volume8
Issue number7
DOIs
StatePublished - Jul 1 2009

Fingerprint

Nanostructured materials
proteins
nanoparticles
organelles
interactions
nanotechnology
Nanoparticles
Proteins
coronas
phase transformations
dissolving
Biomolecules
roughness
Cell membranes
deoxyribonucleic acid
Surface chemistry
free energy
Nanotechnology
chemistry
Free energy

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Nel, A. E., Mädler, L., Velegol, D., Xia, T., Hoek, E. M. V., Somasundaran, P., ... Thompson, M. (2009). Understanding biophysicochemical interactions at the nano-bio interface. Nature Materials, 8(7), 543-557. https://doi.org/10.1038/nmat2442
Nel, Andre E. ; Mädler, Lutz ; Velegol, Darrell ; Xia, Tian ; Hoek, Eric M.V. ; Somasundaran, Ponisseril ; Klaessig, Fred ; Castranova, Vince ; Thompson, Mike. / Understanding biophysicochemical interactions at the nano-bio interface. In: Nature Materials. 2009 ; Vol. 8, No. 7. pp. 543-557.
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Nel, AE, Mädler, L, Velegol, D, Xia, T, Hoek, EMV, Somasundaran, P, Klaessig, F, Castranova, V & Thompson, M 2009, 'Understanding biophysicochemical interactions at the nano-bio interface', Nature Materials, vol. 8, no. 7, pp. 543-557. https://doi.org/10.1038/nmat2442

Understanding biophysicochemical interactions at the nano-bio interface. / Nel, Andre E.; Mädler, Lutz; Velegol, Darrell; Xia, Tian; Hoek, Eric M.V.; Somasundaran, Ponisseril; Klaessig, Fred; Castranova, Vince; Thompson, Mike.

In: Nature Materials, Vol. 8, No. 7, 01.07.2009, p. 543-557.

Research output: Contribution to journalReview article

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Nel AE, Mädler L, Velegol D, Xia T, Hoek EMV, Somasundaran P et al. Understanding biophysicochemical interactions at the nano-bio interface. Nature Materials. 2009 Jul 1;8(7):543-557. https://doi.org/10.1038/nmat2442