Understanding nucleosome dynamics and their links to gene expression and DNA replication

William K.M. Lai, B. Franklin Pugh

Research output: Contribution to journalReview article

119 Scopus citations

Abstract

Advances in genomics technology have provided the means to probe myriad chromatin interactions at unprecedented spatial and temporal resolution. This has led to a profound understanding of nucleosome organization within the genome, revealing that nucleosomes are highly dynamic. Nucleosome dynamics are governed by a complex interplay of histone composition, histone post-translational modifications, nucleosome occupancy and positioning within chromatin, which are influenced by numerous regulatory factors, including general regulatory factors, chromatin remodellers, chaperones and polymerases. It is now known that these dynamics regulate diverse cellular processes ranging from gene transcription to DNA replication and repair.

Original languageEnglish (US)
Pages (from-to)548-562
Number of pages15
JournalNature Reviews Molecular Cell Biology
Volume18
Issue number9
DOIs
StatePublished - Sep 1 2017

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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