Unique Characteristics of the Parasite Polyamine Pathway

Research output: Contribution to journalShort survey

Abstract

A critical function of spermidine is in the formation of hypusine, an essential post-translational modification of eukaryotic initiation factor eIF5A. In this issue of Structure, Afandor et al. (2018) determine the crystal structure of trypanosomal deoxyhypusine synthase, which shows that gene duplication and subsequent mutations provide significant differences from the mammalian equivalent exploitable for drug design. A critical function of spermidine is in the formation of hypusine, an essential post-translational modification of eukaryotic initiation factor eIF5A. In this issue of Structure, Afandor et al. (2018) determine the crystal structure of trypanosomal deoxyhypusine synthase, which shows that gene duplication and subsequent mutations provide significant differences from the mammalian equivalent exploitable for drug design.

Original languageEnglish (US)
Pages (from-to)1427-1429
Number of pages3
JournalStructure
Volume26
Issue number11
DOIs
StatePublished - Nov 6 2018

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Eukaryotic Initiation Factors
Gene Duplication
Spermidine
Drug Design
Polyamines
Post Translational Protein Processing
Parasites
Mutation
hypusine
deoxyhypusine synthase

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

Cite this

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title = "Unique Characteristics of the Parasite Polyamine Pathway",
abstract = "A critical function of spermidine is in the formation of hypusine, an essential post-translational modification of eukaryotic initiation factor eIF5A. In this issue of Structure, Afandor et al. (2018) determine the crystal structure of trypanosomal deoxyhypusine synthase, which shows that gene duplication and subsequent mutations provide significant differences from the mammalian equivalent exploitable for drug design. A critical function of spermidine is in the formation of hypusine, an essential post-translational modification of eukaryotic initiation factor eIF5A. In this issue of Structure, Afandor et al. (2018) determine the crystal structure of trypanosomal deoxyhypusine synthase, which shows that gene duplication and subsequent mutations provide significant differences from the mammalian equivalent exploitable for drug design.",
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Unique Characteristics of the Parasite Polyamine Pathway. / Pegg, Anthony.

In: Structure, Vol. 26, No. 11, 06.11.2018, p. 1427-1429.

Research output: Contribution to journalShort survey

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