Unique Characteristics of the Parasite Polyamine Pathway

Research output: Contribution to journalShort survey

Abstract

A critical function of spermidine is in the formation of hypusine, an essential post-translational modification of eukaryotic initiation factor eIF5A. In this issue of Structure, Afandor et al. (2018) determine the crystal structure of trypanosomal deoxyhypusine synthase, which shows that gene duplication and subsequent mutations provide significant differences from the mammalian equivalent exploitable for drug design. A critical function of spermidine is in the formation of hypusine, an essential post-translational modification of eukaryotic initiation factor eIF5A. In this issue of Structure, Afandor et al. (2018) determine the crystal structure of trypanosomal deoxyhypusine synthase, which shows that gene duplication and subsequent mutations provide significant differences from the mammalian equivalent exploitable for drug design.

Original languageEnglish (US)
Pages (from-to)1427-1429
Number of pages3
JournalStructure
Volume26
Issue number11
DOIs
StatePublished - Nov 6 2018

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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