Unraveling gene regulatory networks using an integrated microfluidic platform

Pak Kin Wong, Fuqu Yu, Ren Sun, Chin Ming Ho

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Systematic investigation of complex cellular systems using micro and nano devices has distinctive advantages over traditional approaches. The capabilities of performing time-varying stimulation and real-time monitoring of cells are invaluable for investigating dynamic biological systems, such as gene regulatory networks. In this work, we report a generic microfluidic platform, which is capable of long term cell cultivation, for investigating the complex dynamics of a transcription factor, nuclear factor kappa B (NF-κB). The temporal responses of NF-κB mediated gene expression were measured at the single cell level and the results were compared to a computational model. Our microfluidic platforms combining with advanced biotechnologies and computational techniques provide powerful tools for investigating complex biological networks.

Original languageEnglish (US)
Title of host publication2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings
Pages291-294
Number of pages4
DOIs
Publication statusPublished - Dec 1 2007
Event2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007 - Hong Kong, China
Duration: Aug 2 2007Aug 5 2007

Publication series

Name2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings

Other

Other2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007
CountryChina
CityHong Kong
Period8/2/078/5/07

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All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics

Cite this

Wong, P. K., Yu, F., Sun, R., & Ho, C. M. (2007). Unraveling gene regulatory networks using an integrated microfluidic platform. In 2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings (pp. 291-294). [4601192] (2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings). https://doi.org/10.1109/NANO.2007.4601192