Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies

Ulrike H.M. Ziegner, Hans D. Ochs, Carolyn Schanen, Stephen A. Feig, Kuniaki Seyama, Takeshi Futatani, Thomas Gross, Mary Wakim, Robert L. Roberts, David J. Rawlings, Sinisa Dovat, John K. Fraser, E. Richard Stiehm

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Banked unrelated umbilical cord blood matched at 5 of 6 human leukocyte antigen loci was used to reconstitute the immune system in 2 brothers with X-linked lymphoproliferative syndrome and 1 boy with X-linked hyperimmunoglobulin-M syndrome. Pretransplant cytoreduction and post-transplant graft-versus-host prophylaxis were given. Hematopoietic engraftment and correction of the genetic defects were documented by molecular techniques. Two years after transplantation, all 3 patients have normal immune systems. These reports support the wider use of banked partially matched cord blood for transplantation in primary immunodeficiencies.

Original languageEnglish (US)
Pages (from-to)570-573
Number of pages4
JournalJournal of Pediatrics
Volume138
Issue number4
DOIs
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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