Update of humanized animal disease models in studying Graft-versus-host disease

Feng Huang, Feng Lin Cao, Song Guo Zheng

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Graft-versus-host disease (GVHD) is a severe adverse effect that results from bone marrow or peripheral blood cells transplantation and has a high rate of mortality. About 50% of the patients are accompanied with acute Graft-versus-Host Disease (aGVHD) after bone marrow cell transplantation and need systematic treatment. It has an important clinical significance to evaluate the prevention and treatment effects of GVHD. The stable and reliable approaches of humanized animal models are crucial for advancing on the study the biology of GVHD. Relative models transplanting the human immune cells into the mouse body can trigger immunoreaction similar to the humans. As it is a disease triggered by human immune cells, any intervention research prior to clinical treatment has more clinical interrelations compared with the general animal models. In this review, we update the current understanding on humanized animal disease models on studying Graft-versus-host disease and expect to provide more theoretical basis to further study on Graft-versus-host disease.

Original languageEnglish (US)
Pages (from-to)2618-2623
Number of pages6
JournalHuman Vaccines and Immunotherapeutics
Volume14
Issue number11
DOIs
StatePublished - Nov 2 2018

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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