Update on Indigestion

Research output: Contribution to journalReview articlepeer-review


Dyspepsia affects a large percentage of the general population and can lead to lost work productivity and reduced quality of life. Patients with dyspepsia younger than 60 should not routinely undergo endoscopy but instead should pursue Helicobacter pylori test-and-treat approach. For patients 60 and older, endoscopy should be performed. Patients without any identifiable cause for their symptoms are diagnosed with functional dyspepsia. Guideline-based treatment includes H pylori eradication and proton pump inhibitor use. If acid suppression is not adequate, treatment with a tricyclic antidepressant followed by a prokinetic agent and psychological therapy are considered. Complementary therapies are not recommended due to limited evidence.

Original languageEnglish (US)
Pages (from-to)19-30
Number of pages12
JournalMedical Clinics of North America
Issue number1
StatePublished - Jan 2021

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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