Morfologia das vias aéreas superiores em pacientes com síndrome de Down sob sedação com dexmedetomidina

Translated title of the contribution: Upper airway morphology in Down Syndrome patients under dexmedetomidine sedation

Rajeev Subramanyam, Robert Fleck, John McAuliffe, Rupa Radhakrishnan, Dorothy Jung, Mario Patino, Mohamed Mahmoud

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Background and objectives: Children with Down Syndrome are vulnerable to significant upper airway obstruction due to relative macroglossia and dynamic airway collapse. The objective of this study was to compare the upper airway dimensions of children with Down Syndrome and obstructive sleep apnea with normal airway under dexmedetomidine sedation. Methods: IRB approval was obtained. In this retrospective study, clinically indicated dynamic sagittal midline magnetic resonance images of the upper airway were obtained under low (1 mcg/kg/h) and high (3 mcg/kg/h) dose dexmedetomidine. Airway anteroposterior diameters and sectional areas were measured as minimum and maximum dimensions by two independent observers at soft palate (nasopharyngeal airway) and at base of the tongue (retroglossal airway). Results and conclusions: Minimum anteroposterior diameter and minimum sectional area at nasopharynx and retroglossal airway were significantly reduced in Down Syndrome compared to normal airway at both low and high dose dexmedetomidine. However, there were no significant differences between low and high dose dexmedetomidine in both Down Syndrome and normal airway. The mean apnea hypopnea index in Down Syndrome was 16 ± 11. Under dexmedetomidine sedation, children with Down Syndrome and obstructive sleep apnea when compared to normal airway children show significant reductions in airway dimensions most pronounced at the narrowest points in the nasopharyngeal and retroglossal airways.

Translated title of the contributionUpper airway morphology in Down Syndrome patients under dexmedetomidine sedation
Original languagePortuguese
Pages (from-to)388-394
Number of pages7
JournalRevista Brasileira de Anestesiologia
Issue number4
StatePublished - Jul 1 2016

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

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