Upregulation of glucose metabolism by granulocyte-monocyte colony-stimulating factor

Ágnes Schuler, Zoltán Spolarics, Charles H. Lang, Gregory J. Bagby, Steve Nelson, John J. Spitzer

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Alterations of glucose metabolism were investigated for 6 hours following an intraarterial injection of murine recombinant granulocyte-monocyte colony-stimulating factor (GM-CSF) (30 μg/k body weight). GM-CSF resulted in a transient elevation of plasma glucose. The rate of whole body glucose appearance, as measured by infusion of [6-3H]glucose, was increased by about 10 % between 0.5 and 3 hours following GM-CSF injection. In vivo glucose utilization of individual tissues was investigated by the tracer 2-deoxyglucose technique. At 30 min, GM-CSF increased glucose utilization by 80-90 % in liver and lung, and 50-60 % in skin and spleen. At 3 and 6 hours, glucose utilization by these tissues returned toward control levels except for lung. There was a 40-50 % increase in glucose utilization by skeletal muscle 30 min after GM-CSF which was sustained for 6 hours. Glucose utilization of testis, ileum and kidney did not change significantly. Plasma concentrations of insulin, glucagon and tumor necrosis factor were not altered in response to GM-CSF. These findings indicate that some of the acute metabolic effects of a short-term administration of GM-CSF are observed in macrophage-rich tissues, and suggest that GM-CSF may be involved in the metabolic upregulation of immunologically active tissues.

Original languageEnglish (US)
Pages (from-to)899-906
Number of pages8
JournalLife Sciences
Volume49
Issue number12
DOIs
StatePublished - 1991

Fingerprint

Colony-Stimulating Factors
Granulocyte Colony-Stimulating Factor
Metabolism
Monocytes
Up-Regulation
Glucose
Tissue
Intra-Arterial Injections
Plasmas
Lung
Macrophages
Level control
Deoxyglucose
Glucagon
Ileum
Liver
Muscle
Testis
Skin
Skeletal Muscle

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Schuler, Ágnes ; Spolarics, Zoltán ; Lang, Charles H. ; Bagby, Gregory J. ; Nelson, Steve ; Spitzer, John J. / Upregulation of glucose metabolism by granulocyte-monocyte colony-stimulating factor. In: Life Sciences. 1991 ; Vol. 49, No. 12. pp. 899-906.
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abstract = "Alterations of glucose metabolism were investigated for 6 hours following an intraarterial injection of murine recombinant granulocyte-monocyte colony-stimulating factor (GM-CSF) (30 μg/k body weight). GM-CSF resulted in a transient elevation of plasma glucose. The rate of whole body glucose appearance, as measured by infusion of [6-3H]glucose, was increased by about 10 {\%} between 0.5 and 3 hours following GM-CSF injection. In vivo glucose utilization of individual tissues was investigated by the tracer 2-deoxyglucose technique. At 30 min, GM-CSF increased glucose utilization by 80-90 {\%} in liver and lung, and 50-60 {\%} in skin and spleen. At 3 and 6 hours, glucose utilization by these tissues returned toward control levels except for lung. There was a 40-50 {\%} increase in glucose utilization by skeletal muscle 30 min after GM-CSF which was sustained for 6 hours. Glucose utilization of testis, ileum and kidney did not change significantly. Plasma concentrations of insulin, glucagon and tumor necrosis factor were not altered in response to GM-CSF. These findings indicate that some of the acute metabolic effects of a short-term administration of GM-CSF are observed in macrophage-rich tissues, and suggest that GM-CSF may be involved in the metabolic upregulation of immunologically active tissues.",
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Schuler, Á, Spolarics, Z, Lang, CH, Bagby, GJ, Nelson, S & Spitzer, JJ 1991, 'Upregulation of glucose metabolism by granulocyte-monocyte colony-stimulating factor', Life Sciences, vol. 49, no. 12, pp. 899-906. https://doi.org/10.1016/0024-3205(91)90175-B

Upregulation of glucose metabolism by granulocyte-monocyte colony-stimulating factor. / Schuler, Ágnes; Spolarics, Zoltán; Lang, Charles H.; Bagby, Gregory J.; Nelson, Steve; Spitzer, John J.

In: Life Sciences, Vol. 49, No. 12, 1991, p. 899-906.

Research output: Contribution to journalArticle

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