Upstream signal transduction of NF-kappaB activation.

Fei Chen, Laurence Demers, Xianglin Shi

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

NF-kappaB is a transcription factor governing the expression of genes involved in the immune response, embryo or cell lineage development, cell apoptosis, cell cycle progression, inflammation, and oncogenesis. During the past few years, considerable attention has been paid to the upstream signaling pathways that lead to the activation of NF-kappaB. Many of these signaling molecules can serve as potential pharmaceutical targets for the specific inhibition of NF-kappaB activation leading to interruption of disease processes. How these molecules interact with each other is however, still a debatable issue. Since many of the signal molecules in this pathway relay more than one of the upstream signals to downstream targets, it has been suggested that the transmission of signals involves a network, rather than a linear sequence in the activation of NF-kappaB. Thus, the detailed elucidation of the upstream signaling molecules involved with NF-kappaB activation will be important to the development of pharmaceutical inhibitors that specifically inhibit the activation of NF-kappaB. Such inhibitors would be predicted to have potent anti-inflammatory and/or anti-carcinogenic effects.

Original languageEnglish (US)
Pages (from-to)137-149
Number of pages13
JournalCurrent drug targets. Inflammation and allergy
Volume1
Issue number2
StatePublished - Jan 1 2002

Fingerprint

NF-kappa B
Signal Transduction
Anticarcinogenic Agents
Cell Lineage
Pharmaceutical Preparations
Cell Cycle
Carcinogenesis
Anti-Inflammatory Agents
Transcription Factors
Embryonic Structures
Apoptosis
Inflammation
Gene Expression

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Chen, Fei ; Demers, Laurence ; Shi, Xianglin. / Upstream signal transduction of NF-kappaB activation. In: Current drug targets. Inflammation and allergy. 2002 ; Vol. 1, No. 2. pp. 137-149.
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Chen, F, Demers, L & Shi, X 2002, 'Upstream signal transduction of NF-kappaB activation.', Current drug targets. Inflammation and allergy, vol. 1, no. 2, pp. 137-149.

Upstream signal transduction of NF-kappaB activation. / Chen, Fei; Demers, Laurence; Shi, Xianglin.

In: Current drug targets. Inflammation and allergy, Vol. 1, No. 2, 01.01.2002, p. 137-149.

Research output: Contribution to journalReview article

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AU - Shi, Xianglin

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AB - NF-kappaB is a transcription factor governing the expression of genes involved in the immune response, embryo or cell lineage development, cell apoptosis, cell cycle progression, inflammation, and oncogenesis. During the past few years, considerable attention has been paid to the upstream signaling pathways that lead to the activation of NF-kappaB. Many of these signaling molecules can serve as potential pharmaceutical targets for the specific inhibition of NF-kappaB activation leading to interruption of disease processes. How these molecules interact with each other is however, still a debatable issue. Since many of the signal molecules in this pathway relay more than one of the upstream signals to downstream targets, it has been suggested that the transmission of signals involves a network, rather than a linear sequence in the activation of NF-kappaB. Thus, the detailed elucidation of the upstream signaling molecules involved with NF-kappaB activation will be important to the development of pharmaceutical inhibitors that specifically inhibit the activation of NF-kappaB. Such inhibitors would be predicted to have potent anti-inflammatory and/or anti-carcinogenic effects.

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