Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in puerto rican adults

Xiang Gao, Chao Qiang Lai, Tammy Scott, Jian Shen, Tianxi Cai, Jose M. Ordovas, Katherine L. Tucker

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Abstract

DNA oxidative stress has been suggested as an important pathogenic mechanism in cognitive impairment and dementia. With baseline data collected from 2004 to 2008, the authors examined whether urinary 8-hydroxy-2- deoxyguanosine (8-OHdG), a biomarker of global DNA oxidation, was associated with cognitive function in a sample of 1,003 Puerto Rican adults, aged 45-75 years, living in Boston, Massachusetts, and the surrounding area. Cognitive function was measured by using a battery of 7 tests: the Mini-Mental State Examination, word list learning, digit span, clock drawing and figure copying, Stroop, and verbal fluency tests. The primary outcome was a global cognitive score, averaging standardized scores across all cognitive tests. A higher 8-OHdG concentration was significantly associated with lower global cognitive scores, after adjustment for age, education, status of the gene for apolipoprotein E (APOE), and other covariates (Ptrend = 0.01). The difference in the global score, comparing participants in the 2 extreme 8-OHdG quartiles, was-0.11 (95% confidence interval:-0.20,-0.02), which was equivalent to accelerating cognitive aging by about 4 years, as observed in this population. Prospective studies are needed to elucidate whether elevated urinary 8-OHdG concentrations can predict the rate of cognitive decline and incident dementia.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
JournalAmerican journal of epidemiology
Volume172
Issue number3
DOIs
StatePublished - Aug 1 2010

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All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Gao, X., Lai, C. Q., Scott, T., Shen, J., Cai, T., Ordovas, J. M., & Tucker, K. L. (2010). Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in puerto rican adults. American journal of epidemiology, 172(3), 271-278. https://doi.org/10.1093/aje/kwq136