Urinary excretion of prostaglandin E following the administration of furosemide and indomethacin to sick low-birth-weight infants

Zvi Friedman, Laurence Demers, Keith H. Marks, Susan Uhrmann, M. Jeffrey Maisels

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Urinary excretion of prostaglandin E was measured in seven sick low-birth-weight infants. Four had severe hyaline membrane disease and one had chronic bronchopulmonary dysplasia; all received furosemide. Two infants had patent ductus arteriosus and received indomethacin. Following administration of furosemide, Urine volume and the excretion rates of sodium and calcium were significantly increased; such changes were not seen following the administration of indomethacin. Prostaglandin E excretion rate was increased from 0.4 ± 0.04 to 1.3 ± 0.2 ng/mg Cr (mean ± SEM) following administration of furosemide, but decreased in two patients following administration of indomethacin. The present results demonstrate that furosemide enhances urinary excretion of prostaglandin E by mechanisms which may reflect an increase in prostaglandin synthesis, a decrease in prostaglandin renal metabolism, or both. Indomethacin, which is a prostaglandin synthetase inhibitor, decreases the urinary excretion of prostaglandin E. These observations suggest that furosemide therapy in patients receiving indomethacin may be ineffective.

Original languageEnglish (US)
Pages (from-to)512-515
Number of pages4
JournalJournal of Pediatrics
Volume93
Issue number3
DOIs
StatePublished - Jan 1 1978

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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