Urinary fibrinopeptide A in evaluation of patients with suspected acute pulmonary embolism; A prospective pilot study

M. Tulchinsky, J. A. Zeller, R. C. Reba

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This pilot study assessed the urinary fibrinopeptide A (uFPA) levels and the combination of uFPA test plus ventilation/perfusion (V/Q) scan in the diagnostic evaluation of acute pulmonary embolism (PE). One hundred consecutive patients were studied prospectively. Twenty-nine patients fulfilled diagnostic criteria defined in this study (seven with and 22 without PE). The uFPA concentration was significantly higher in patients with than without PE (41.1±2.6 vs 4.8±2.5 ng/mg of creatinine, p<0.0001). In all patients with PE, the uFPA levels were higher than threshold value derived by adding 2 standard deviations to the mean uFPA concentration of patients without PE. In patients without PE, the V/Q scan was negative in 16, the uFPA test was negative in 18, and at least one of the tests was negative in 21. These preliminary data suggest that a negative uFPA test may be helpful in excluding PE and that uFPA in combination with V/Q lung scans may correctly exclude PE in more patients than either test alone. Further studies in a large unselected population are needed to confirm these results.

Original languageEnglish (US)
Pages (from-to)394-398
Number of pages5
JournalCHEST
Volume100
Issue number2
DOIs
StatePublished - Jan 1 1991

Fingerprint

Fibrinopeptide A
Pulmonary Embolism
Prospective Studies
Pulmonary Ventilation
Creatinine
Perfusion
Lung

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

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abstract = "This pilot study assessed the urinary fibrinopeptide A (uFPA) levels and the combination of uFPA test plus ventilation/perfusion (V/Q) scan in the diagnostic evaluation of acute pulmonary embolism (PE). One hundred consecutive patients were studied prospectively. Twenty-nine patients fulfilled diagnostic criteria defined in this study (seven with and 22 without PE). The uFPA concentration was significantly higher in patients with than without PE (41.1±2.6 vs 4.8±2.5 ng/mg of creatinine, p<0.0001). In all patients with PE, the uFPA levels were higher than threshold value derived by adding 2 standard deviations to the mean uFPA concentration of patients without PE. In patients without PE, the V/Q scan was negative in 16, the uFPA test was negative in 18, and at least one of the tests was negative in 21. These preliminary data suggest that a negative uFPA test may be helpful in excluding PE and that uFPA in combination with V/Q lung scans may correctly exclude PE in more patients than either test alone. Further studies in a large unselected population are needed to confirm these results.",
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Urinary fibrinopeptide A in evaluation of patients with suspected acute pulmonary embolism; A prospective pilot study. / Tulchinsky, M.; Zeller, J. A.; Reba, R. C.

In: CHEST, Vol. 100, No. 2, 01.01.1991, p. 394-398.

Research output: Contribution to journalArticle

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