Urinary polyamine levels in human cancer

Allan Lipton, Linda M. Sheehan, Georg Frederick Kessler

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Polyamine levels (putrescine, spermidine, spermine) were determined in 24‐hour urine samples by a high voltage electrophoresis technique. Normal values were established in 42 normal volunteers. Thirty‐eight of 56 patients with metastatic cancer had two or more levels elevated. Approximately two‐thirds of patients with metastatic adenocarcinoma. metastatic squamous cell cancer or metastatic disease to the liver, lungs, or bones had elevated levels. All 6 patients with localized malignant tumors had elevated urinary polyamine levels. Elevations were also seen in patients with benign prostatic hypertrophy and bronchial adenoma.

Original languageEnglish (US)
Pages (from-to)464-468
Number of pages5
JournalCancer
Volume35
Issue number2
DOIs
StatePublished - Feb 1975

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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