Urinary polyamine levels in patients with localized malignancy

Allan Lipton, Linda Sheehan, Rodrique Mortel, Harold Harvey

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Polyamine levels (putrescine, spermidine, and spermine) were determined in 24‐hour urine samples by a high voltage electrophoresis technique. Twentyfour of 26 patients with localized malignant tumors had two or more elevated urinary polyamine levels. Seven of 12 patients with regional spread of their cancer and five of 11 patients with localized benign and/or noninvasive tumors had elevated urinary polyamine levels. Elevations were seen more frequently in patients with genitourinary, gastrointestinal, and pulmonary tumors and less frequently in patients with gynecologic tumors. Our data suggest that there is no significant difference between the individual or total polyamine levels obtained in patients with localized malignant tumors, and those levels obtained in patients previously studied with widespread metastatic disease.

Original languageEnglish (US)
Pages (from-to)1344-1347
Number of pages4
JournalCancer
Volume38
Issue number3
DOIs
StatePublished - Jan 1 1976

Fingerprint

Polyamines
Neoplasms
Putrescine
Spermidine
Spermine
Individuality
Electrophoresis
Urine
Lung

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lipton, Allan ; Sheehan, Linda ; Mortel, Rodrique ; Harvey, Harold. / Urinary polyamine levels in patients with localized malignancy. In: Cancer. 1976 ; Vol. 38, No. 3. pp. 1344-1347.
@article{19732a22cf2942aeb9a3caec2259f5d1,
title = "Urinary polyamine levels in patients with localized malignancy",
abstract = "Polyamine levels (putrescine, spermidine, and spermine) were determined in 24‐hour urine samples by a high voltage electrophoresis technique. Twentyfour of 26 patients with localized malignant tumors had two or more elevated urinary polyamine levels. Seven of 12 patients with regional spread of their cancer and five of 11 patients with localized benign and/or noninvasive tumors had elevated urinary polyamine levels. Elevations were seen more frequently in patients with genitourinary, gastrointestinal, and pulmonary tumors and less frequently in patients with gynecologic tumors. Our data suggest that there is no significant difference between the individual or total polyamine levels obtained in patients with localized malignant tumors, and those levels obtained in patients previously studied with widespread metastatic disease.",
author = "Allan Lipton and Linda Sheehan and Rodrique Mortel and Harold Harvey",
year = "1976",
month = "1",
day = "1",
doi = "10.1002/1097-0142(197609)38:3<1344::AID-CNCR2820380338>3.0.CO;2-Y",
language = "English (US)",
volume = "38",
pages = "1344--1347",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

Urinary polyamine levels in patients with localized malignancy. / Lipton, Allan; Sheehan, Linda; Mortel, Rodrique; Harvey, Harold.

In: Cancer, Vol. 38, No. 3, 01.01.1976, p. 1344-1347.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Urinary polyamine levels in patients with localized malignancy

AU - Lipton, Allan

AU - Sheehan, Linda

AU - Mortel, Rodrique

AU - Harvey, Harold

PY - 1976/1/1

Y1 - 1976/1/1

N2 - Polyamine levels (putrescine, spermidine, and spermine) were determined in 24‐hour urine samples by a high voltage electrophoresis technique. Twentyfour of 26 patients with localized malignant tumors had two or more elevated urinary polyamine levels. Seven of 12 patients with regional spread of their cancer and five of 11 patients with localized benign and/or noninvasive tumors had elevated urinary polyamine levels. Elevations were seen more frequently in patients with genitourinary, gastrointestinal, and pulmonary tumors and less frequently in patients with gynecologic tumors. Our data suggest that there is no significant difference between the individual or total polyamine levels obtained in patients with localized malignant tumors, and those levels obtained in patients previously studied with widespread metastatic disease.

AB - Polyamine levels (putrescine, spermidine, and spermine) were determined in 24‐hour urine samples by a high voltage electrophoresis technique. Twentyfour of 26 patients with localized malignant tumors had two or more elevated urinary polyamine levels. Seven of 12 patients with regional spread of their cancer and five of 11 patients with localized benign and/or noninvasive tumors had elevated urinary polyamine levels. Elevations were seen more frequently in patients with genitourinary, gastrointestinal, and pulmonary tumors and less frequently in patients with gynecologic tumors. Our data suggest that there is no significant difference between the individual or total polyamine levels obtained in patients with localized malignant tumors, and those levels obtained in patients previously studied with widespread metastatic disease.

UR - http://www.scopus.com/inward/record.url?scp=0017168003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017168003&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(197609)38:3<1344::AID-CNCR2820380338>3.0.CO;2-Y

DO - 10.1002/1097-0142(197609)38:3<1344::AID-CNCR2820380338>3.0.CO;2-Y

M3 - Article

C2 - 953972

AN - SCOPUS:0017168003

VL - 38

SP - 1344

EP - 1347

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 3

ER -