Use of implantable pumps for central nervous system drug infusions to treat neurological disease

Robert Harbaugh, R. L. Saunders, R. F. Reeder

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

Increasing knowledge of the neurochemical aspects of central nervous system function raises the possibility of treating neurological disease by the appropriate manipulation of neurotransmitters, neuromodulators, and neurohormones. Clinical application of this knowledge has been inhibited, however, by long-standing problems with drug delivery to the central nervous system (CNS). The availability of implantable drug infusion pumps and stereotactic catheter placement techniques may overcome many of these problems. The problems of drug delivery to the brain and the present and potential uses of implantable drug pumps for neurological disease are discussed. In addition, the relationship between CNS drug infusion and neural tissue transplantation is briefly reviewed.

Original languageEnglish (US)
Pages (from-to)693-698
Number of pages6
JournalNeurosurgery
Volume23
Issue number6
DOIs
StatePublished - Jan 1 1988

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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