Use of magnetic resonance imaging and p‐31 magnetic resonance spectroscopy to detect and quantify muscle dysfunction in the amyopathic and myopathic variants of dermatomyositis

Jane H. Park, Nancy J. Olsen, Lloyd King, Jr, Terri Vital, Robert Buse, Suresh Kari, Marta Hernanz Schulman, Ronald R. Price

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Objective. To investigate the use of magnetic resonance imaging (MRI) and P‐31 magnetic resonance spectroscopy (MRS) in characterizing the metabolic and functional status of muscles in patients with amyopathic dermatomyositis (DM) and to compare the findings with those in patients with classic myopathic DM. Methods. Nine patients with amyopathic DM, 11 patients with myopathic DM, and 11 normal individuals were studied. MRI images of thigh muscles were obtained, and T1 and T2 relaxation times were calculated. Biochemical status was quantitated with P‐31 MRS, by determining concentrations of phosphate metabolites during rest and exercise. Results. Patients with amyopathic DM showed no muscle inflammation, and MRS data obtained during rest were normal. During exercise at 25% and 50% maximum voluntary contractile force, the MRS data revealed significant differences between amyopathic DM patients and control subjects indicating inefficient metabolism. In contrast, muscles of patients with myopathic DM showed inflammation and metabolic abnormalities even during rest. Conclusion. Metabolic deficiencies in patients with amyopathic DM were unmasked by exercise, suggesting that the 2 DM syndromes may share muscle abnormalities. MRI/MRS may be useful in diagnosis and optimization of treatment.

Original languageEnglish (US)
Pages (from-to)68-77
Number of pages10
JournalArthritis & Rheumatism
Volume38
Issue number1
DOIs
StatePublished - Jan 1995

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Dermatomyositis
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Muscles
Exercise
Inflammation
Thigh
Phosphates
Amyopathic dermatomyositis

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Park, Jane H. ; Olsen, Nancy J. ; Jr, Lloyd King, ; Vital, Terri ; Buse, Robert ; Kari, Suresh ; Schulman, Marta Hernanz ; Price, Ronald R. / Use of magnetic resonance imaging and p‐31 magnetic resonance spectroscopy to detect and quantify muscle dysfunction in the amyopathic and myopathic variants of dermatomyositis. In: Arthritis & Rheumatism. 1995 ; Vol. 38, No. 1. pp. 68-77.
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abstract = "Objective. To investigate the use of magnetic resonance imaging (MRI) and P‐31 magnetic resonance spectroscopy (MRS) in characterizing the metabolic and functional status of muscles in patients with amyopathic dermatomyositis (DM) and to compare the findings with those in patients with classic myopathic DM. Methods. Nine patients with amyopathic DM, 11 patients with myopathic DM, and 11 normal individuals were studied. MRI images of thigh muscles were obtained, and T1 and T2 relaxation times were calculated. Biochemical status was quantitated with P‐31 MRS, by determining concentrations of phosphate metabolites during rest and exercise. Results. Patients with amyopathic DM showed no muscle inflammation, and MRS data obtained during rest were normal. During exercise at 25{\%} and 50{\%} maximum voluntary contractile force, the MRS data revealed significant differences between amyopathic DM patients and control subjects indicating inefficient metabolism. In contrast, muscles of patients with myopathic DM showed inflammation and metabolic abnormalities even during rest. Conclusion. Metabolic deficiencies in patients with amyopathic DM were unmasked by exercise, suggesting that the 2 DM syndromes may share muscle abnormalities. MRI/MRS may be useful in diagnosis and optimization of treatment.",
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Use of magnetic resonance imaging and p‐31 magnetic resonance spectroscopy to detect and quantify muscle dysfunction in the amyopathic and myopathic variants of dermatomyositis. / Park, Jane H.; Olsen, Nancy J.; Jr, Lloyd King,; Vital, Terri; Buse, Robert; Kari, Suresh; Schulman, Marta Hernanz; Price, Ronald R.

In: Arthritis & Rheumatism, Vol. 38, No. 1, 01.1995, p. 68-77.

Research output: Contribution to journalArticle

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N2 - Objective. To investigate the use of magnetic resonance imaging (MRI) and P‐31 magnetic resonance spectroscopy (MRS) in characterizing the metabolic and functional status of muscles in patients with amyopathic dermatomyositis (DM) and to compare the findings with those in patients with classic myopathic DM. Methods. Nine patients with amyopathic DM, 11 patients with myopathic DM, and 11 normal individuals were studied. MRI images of thigh muscles were obtained, and T1 and T2 relaxation times were calculated. Biochemical status was quantitated with P‐31 MRS, by determining concentrations of phosphate metabolites during rest and exercise. Results. Patients with amyopathic DM showed no muscle inflammation, and MRS data obtained during rest were normal. During exercise at 25% and 50% maximum voluntary contractile force, the MRS data revealed significant differences between amyopathic DM patients and control subjects indicating inefficient metabolism. In contrast, muscles of patients with myopathic DM showed inflammation and metabolic abnormalities even during rest. Conclusion. Metabolic deficiencies in patients with amyopathic DM were unmasked by exercise, suggesting that the 2 DM syndromes may share muscle abnormalities. MRI/MRS may be useful in diagnosis and optimization of treatment.

AB - Objective. To investigate the use of magnetic resonance imaging (MRI) and P‐31 magnetic resonance spectroscopy (MRS) in characterizing the metabolic and functional status of muscles in patients with amyopathic dermatomyositis (DM) and to compare the findings with those in patients with classic myopathic DM. Methods. Nine patients with amyopathic DM, 11 patients with myopathic DM, and 11 normal individuals were studied. MRI images of thigh muscles were obtained, and T1 and T2 relaxation times were calculated. Biochemical status was quantitated with P‐31 MRS, by determining concentrations of phosphate metabolites during rest and exercise. Results. Patients with amyopathic DM showed no muscle inflammation, and MRS data obtained during rest were normal. During exercise at 25% and 50% maximum voluntary contractile force, the MRS data revealed significant differences between amyopathic DM patients and control subjects indicating inefficient metabolism. In contrast, muscles of patients with myopathic DM showed inflammation and metabolic abnormalities even during rest. Conclusion. Metabolic deficiencies in patients with amyopathic DM were unmasked by exercise, suggesting that the 2 DM syndromes may share muscle abnormalities. MRI/MRS may be useful in diagnosis and optimization of treatment.

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