TY - JOUR
T1 - Use of magnetoelastic sensors for quantifying platelet aggregation II
T2 - Distinguishing contributions of fibrin and thrombin to the coagulation kinetics of whole blood
AU - Roy, Somnath C.
AU - Werner, Jacob Robert
AU - Mambrini, Giovanni
AU - Grimes, Craig A.
PY - 2008/4/1
Y1 - 2008/4/1
N2 - We report on the use of magnetoelastic sensors for distinguishing the effects of fibrin networks, platelet aggregation, and thrombin generation in the clotting of whole blood. Samples of bovine whole blood are treated with reptilase, ADIP, and kaolin activators to generate clots based on fibrin networks, platelet aggregation, and thrombin respectively. The strengths of these clots are measured by tracking the resonance amplitude of the magnetoelastic sensors immersed in these blood samples as a function of time; the magnitude of the change in resonance amplitude, as the blood sample transforms from liquid to solid, increases with increasing clot strength. The characteristic behavior of the magnetoelastic sensors under different clotting conditions is used to quantify the extent of platelet aggregation due to ADP activator without interference from fibrin or thrombin activities. This work establishes the effectiveness of the magnetoelastic sensing technology as a simple, portable, and cost effective tool for platelet function analysis and quantifying the effects of anti-platelet therapies.
AB - We report on the use of magnetoelastic sensors for distinguishing the effects of fibrin networks, platelet aggregation, and thrombin generation in the clotting of whole blood. Samples of bovine whole blood are treated with reptilase, ADIP, and kaolin activators to generate clots based on fibrin networks, platelet aggregation, and thrombin respectively. The strengths of these clots are measured by tracking the resonance amplitude of the magnetoelastic sensors immersed in these blood samples as a function of time; the magnitude of the change in resonance amplitude, as the blood sample transforms from liquid to solid, increases with increasing clot strength. The characteristic behavior of the magnetoelastic sensors under different clotting conditions is used to quantify the extent of platelet aggregation due to ADP activator without interference from fibrin or thrombin activities. This work establishes the effectiveness of the magnetoelastic sensing technology as a simple, portable, and cost effective tool for platelet function analysis and quantifying the effects of anti-platelet therapies.
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U2 - 10.1166/sl.2008.035
DO - 10.1166/sl.2008.035
M3 - Article
AN - SCOPUS:58049209531
VL - 6
SP - 285
EP - 289
JO - Sensor Letters
JF - Sensor Letters
SN - 1546-198X
IS - 2
ER -