Use of mycophenolate mofetil in the treatment of paraneoplastic pemphigus

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Paraneoplastic pemphigus (PNP) is a rare autoimmune blistering disease with circulating antibodies that bind the cell surface of the epidermis and other non-stratifying epithelia, and immunoprecipitate a complex of four or five proteins (250 kDa, 230 kDa, 210 kDa, 190 kDa and occasionally 170 kDa). Combinations of immunosuppressive agents are usually required to obtain even partial control of the skin lesions. Mucous membrane lesions are refractory to treatment. We describe a patient with PNP whose skin and oral lesions are quiescent following treatment with oral mycophenolate mofetil.

Original languageEnglish (US)
Pages (from-to)506-508
Number of pages3
JournalBritish Journal of Dermatology
Volume142
Issue number3
DOIs
StatePublished - Mar 30 2000

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Mycophenolic Acid
Pemphigus
Skin
Immunosuppressive Agents
Epidermis
Autoimmune Diseases
Mucous Membrane
Epithelium
Antibodies
Therapeutics
Proteins

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

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abstract = "Paraneoplastic pemphigus (PNP) is a rare autoimmune blistering disease with circulating antibodies that bind the cell surface of the epidermis and other non-stratifying epithelia, and immunoprecipitate a complex of four or five proteins (250 kDa, 230 kDa, 210 kDa, 190 kDa and occasionally 170 kDa). Combinations of immunosuppressive agents are usually required to obtain even partial control of the skin lesions. Mucous membrane lesions are refractory to treatment. We describe a patient with PNP whose skin and oral lesions are quiescent following treatment with oral mycophenolate mofetil.",
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Use of mycophenolate mofetil in the treatment of paraneoplastic pemphigus. / Williams, J. V.; Marks, James; Billingsley, Elizabeth.

In: British Journal of Dermatology, Vol. 142, No. 3, 30.03.2000, p. 506-508.

Research output: Contribution to journalArticle

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